49677-01-2Relevant articles and documents
A practical method for N-cyanation of secondary amines and sulfonamides
Hang, Zhaojun,Tong, Xiaowei,Li, Zuowa,Wang, Zhao-yan,Xue, Weihua
supporting information, (2022/02/07)
Cyanamides are an important class of molecules. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1, 2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.
Novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides by using pentavalent iodine reagents in combination with tetraethylammonium bromide
Chaudhari, Kiran H.,Mahajan, Ulhas S.,Bhalerao, Dinesh S.,Akamanchi, Krishnacharya G.
, p. 2815 - 2818 (2008/02/12)
Novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides using pentavalent iodine reagents and tetraethylammonium bromide is discussed. The advantages of this system are use of non toxic reagents, shorter reaction times and moderate to good yields. Georg Thieme Verlag Stuttgart.