49677-01-2Relevant academic research and scientific papers
A practical method for N-cyanation of secondary amines and sulfonamides
Hang, Zhaojun,Tong, Xiaowei,Li, Zuowa,Wang, Zhao-yan,Xue, Weihua
supporting information, (2022/02/07)
Cyanamides are an important class of molecules. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1, 2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.
Iridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Cyanamides
Hashimoto, Toru,Ishii, Satoshi,Yano, Reiko,Miura, Hiroki,Sakata, Ken,Takeuchi, Ryo
, p. 3901 - 3916 (2016/01/25)
The complex [Ir(cod)Cl]2/DPPF or rac-BINAP is an efficient catalyst for the [2+2+2] cycloaddition of α,ω-diynes with cyanamides. A wide range of cyanamides derived from secondary amines are good coupling partners for α,ω-diynes. The reaction of
Novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides by using pentavalent iodine reagents in combination with tetraethylammonium bromide
Chaudhari, Kiran H.,Mahajan, Ulhas S.,Bhalerao, Dinesh S.,Akamanchi, Krishnacharya G.
, p. 2815 - 2818 (2008/02/12)
Novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides using pentavalent iodine reagents and tetraethylammonium bromide is discussed. The advantages of this system are use of non toxic reagents, shorter reaction times and moderate to good yields. Georg Thieme Verlag Stuttgart.
Some Extensions of von Braun (BrCN) Reaction on Organic Bases: Part II
Malik, Abdul,Afza, Nighat,Siddiqui, Salimuzzaman
, p. 512 - 518 (2007/10/02)
Extensions of von Braun Cyanogen bromide reaction on Ephedra alkaloids and simpler bases have resulted in synthesis of substituted oxazolidines and a whole series of nitrogen analogues of ephedrine, desoxy ephedrine and simpler amines.The general applicability and limitations of such extension of the reaction are also discussed. - Key words: von Braun Cyanogen Bromide Reaction
