496808-75-4

Upstream product

• 108549-23-1 Dibenzyl N,N-diisopropylphosphoramidite 
• 331679-26-6 2,3-O-(D-1,7,7-trimethylbicyclo[2.2.1]hept-6-ylidene)-D-myo-inositol 
• 496921-95-0 C₁₆H₂₆O₆C₁₆H₁₈Si 
• 142563-77-7 1D-1-O-(tert-butyldiphenylsilyl)-2,6-O-bis(methoxymethylene)-3,4,5-O-trisbenzoyl-myo-inositol 
• 142534-57-4 1D-1-O-(tert-butyldiphenylsilyl)-3,4,5-O-trisbenzoyl-myo-inositol 
• 142534-58-5 1D-1-O-(tert-butyldiphenylsilyl)-2,6-O-bis(methoxymethylene)-myo-inositol 
• 142534-54-1 1D-1-O-(tert-butyldiphenylsilyl)-myo-inositol 
• 496808-74-3 1D-1-O-(tert-butyldiphenylsilyl)-2,6-O-bis(methoxymethylene)-myo-inositol 3,4,5-tris(dibenzyl phosphate) 

Downstream Products

• 496808-76-5 1D-1-O-(1,2-dipalmitoyl-O-sn-glycerol-3-O-methylphospho)-2,6-O-bis(methoxymethylene)-myo-inositol 3,4,5-tris(dibenzyl phosphate) 

Relevant academic research and scientific papers

Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols

Studies of cellular signal transduction mechanisms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinositols require easy access to these naturally occurring products. Although numerous synthetic methods have been developed during the past decade, most of these methods suffer from excessive length and lack of generality. In this work we describe the comprehensive and uniform synthesis of all naturally occurring phosphatidylinositols such as phosphatidylinositol, phosphatidylinositol 3-phosphate, 4-phosphate, 5-phosphate, 3,4-bisphosphate, 3,5-bisphosphate, 4,5-bisphosphate, and 3,4,5-trisphosphate, featuring both saturated and unsaturated fatty acid chains.

General synthesis of phosphatidylinositol 3-phosphates

Uniform synthetic approach to phosphatidylinositol 3-phosphate, 3,4-bisphosphate and 3,4,5-trisphosphate has been elaborated starting from 1D-1-O-tert-butyldiphenylsilyl- and 1,6-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-myo-inositols using regioselec