142563-77-7Relevant academic research and scientific papers
Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate
Zhang, Honglu,Xu, Yong,Markadieu, Nicolas,Beauwens, Renaud,Erneux, Christophe,Prestwich, Glenn D.
, p. 762 - 766 (2008/09/19)
Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT
Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols
Kubiak, Robert J.,Bruzik, Karol S.
, p. 960 - 968 (2007/10/03)
Studies of cellular signal transduction mechanisms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinositols require easy access to these naturally occurring products. Although numerous synthetic methods have been developed during the past decade, most of these methods suffer from excessive length and lack of generality. In this work we describe the comprehensive and uniform synthesis of all naturally occurring phosphatidylinositols such as phosphatidylinositol, phosphatidylinositol 3-phosphate, 4-phosphate, 5-phosphate, 3,4-bisphosphate, 3,5-bisphosphate, 4,5-bisphosphate, and 3,4,5-trisphosphate, featuring both saturated and unsaturated fatty acid chains.
General synthesis of phosphatidylinositol 3-phosphates
Bruzik, Karol S.
, p. 2415 - 2418 (2007/10/02)
Uniform synthetic approach to phosphatidylinositol 3-phosphate, 3,4-bisphosphate and 3,4,5-trisphosphate has been elaborated starting from 1D-1-O-tert-butyldiphenylsilyl- and 1,6-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-myo-inositols using regioselec
Efficient and systematic syntheses of enantiomerically pure and regiospecifically protected myo-inositols
Bruzik, Karol S.,Tsai, Ming-Daw
, p. 6361 - 6374 (2007/10/02)
Efficient and systematic syntheses of a variety of enantiomerically pure and regiospecifically protected myo-inositols, which can be readily used as precursors for most natural and unnatural derivatives of myo-inositol, have been developed. The key strate
