49681-33-6

Usage

Uses

Used in Pharmaceutical Industry:
N-(1-(naphthalen-1-yl)ethyl)forMaMide is used as a synthetic intermediate for the preparation of S(-)-1-(1''-naphthyl) ethanol, which is an important compound in the synthesis of mevinic acid analogs. Mevinic acid analogs have potential applications in the development of pharmaceuticals targeting cholesterol synthesis and related conditions.
Used in Chemical Synthesis:
In the chemical industry, N-(1-(naphthalen-1-yl)ethyl)forMaMide serves as an intermediate in the preparation of (R)-(+)-1-(1-naphthyl)ethylamine, which is a key compound in the synthesis of cinacalcet. Cinacalcet is a drug used to treat secondary hyperparathyroidism in patients with chronic kidney disease, as well as primary hyperparathyroidism.
These applications highlight the versatility of N-(1-(naphthalen-1-yl)ethyl)forMaMide as a synthetic intermediate in the development of pharmaceuticals and other chemical products. Its unique structure and properties make it a valuable compound for researchers and chemists in various fields.

Upstream product

• 941-98-0 1'-naphthacetophenone 
• 16712-16-6 ammonium formate 
• 50-00-0 formaldehyd 
• 42882-31-5 (RS)-1-(1-naphthyl)ethylamine 
• 67-56-1 methanol 

Downstream Products

• 941-98-0 1'-naphthacetophenone 
• 42882-31-5 (RS)-1-(1-naphthyl)ethylamine 

Relevant academic research and scientific papers

Copper-Catalyzed Formylation of Amines by using Methanol as the C1 Source

Cu/TEMPO catalyst systems are known for the selective transformation of alcohols to aldehydes, as well as for the simultaneous coupling of alcohols and amines to imines under oxidative conditions. In this study, such a Cu/TEMPO catalyst system is found to catalyze the N-formylation of a variety of amines by initial oxidative activation of methanol as the carbonyl source via formaldehyde and formation of N,O-hemiacetals and oxidation of the latter under very mild conditions. A vast range of amines, including aromatic and aliphatic, primary and secondary, and linear and cyclic amines are formylated under these conditions with good to excellent yields. Moreover, paraformaldehyde can be used instead of methanol for the N-formylation.

Bioinspired organocatalytic aerobic C-H oxidation of amines with an ortho -quinone catalyst

A simple bioinspired ortho-quinone catalyst for the aerobic oxidative dehydrogenation of amines to imines is reported. Without any metal cocatalysts, the identified optimal ortho-quinone catalyst enables the oxidations of α-branched primary amines and cyclic secondary amines. Mechanistic studies have disclosed the origins of different performances of ortho-quinone vs para-quinone in biomimetic amine oxidations.

N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor

There is disclosed an N-(α-alkylbenzylidene)-α-phenylalkylamine represented by the general formula (1): STR1 wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X represents a halogen atom or a lower alkoxy group, its use and a process for producing the same and processes for producing intermediates therefor.