49685-65-6

Upstream product

• 487-68-3 mesytaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 860538-02-9 2-amino-1-mesityl-2-phenylethane-1-one 
• 63809-18-7 2-Hydroxy-2-(2',4',6'-trimethylphenyl)ethanoic amide 
• 1346425-01-1 1-(2,4,6-trimethylbenzyl)pyrrolidine-2-carbonitrile 
• 487-68-3 mesytaldehyde 
• 480-63-7 mesitylenecarboxylic acid 
• 55878-82-5 2,4,6-trimethyl-α-oxobenzeneacetonitrile 
• 63809-19-8 2,4,6-trimethyl-mandelic acid-methyl ester 
• 63809-16-5 (R)-[(S)-Methoxycarbonyl-(2,4,6-trimethyl-phenyl)-methoxy]-(2,4,6-trimethyl-phenyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

CO2-Enabled Cyanohydrin Synthesis and Facile Iterative Homologation Reactions**

Thermodynamic and kinetic control of a chemical process is the key to access desired products and states. Changes are made when a desired product is not accessible; one may manipulate the reaction with additional reagents, catalysts and/or protecting groups. Here we report the use of carbon dioxide to accelerate cyanohydrin synthesis under neutral conditions with an insoluble cyanide source (KCN) without generating toxic HCN. Under inert atmosphere, the reaction is essentially not operative due to the unfavored equilibrium. The utility of CO2-mediated selective cyanohydrin synthesis was further showcased by broadening Kiliani–Fischer synthesis under neutral conditions. This protocol offers an easy access to a variety of polyols, cyanohydrins, linear alkylnitriles, by simply starting from alkyl- and arylaldehydes, KCN and an atmospheric pressure of CO2.

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).

Redox-neutral α-cyanation of amines

α-Aminonitriles inaccessible by traditional Strecker chemistry are obtained in redox-neutral fashion by direct amine α-cyanation/N-alkylation or alternatively, α-aminonitrile isomerization. These unprecedented transformations are catalyzed by simple carboxylic acids.

Trimethylsilyl bis(fluorosulfonyl)imide: An efficient catalyst for the addition of trimethylsilyl cyanide to carbonyl compounds

In the presence of 1 mol% of trimethylsilyl bis(fluorosulfonyl)imide, trimethylsilyl cyanide adds efficiently to carbonyl compounds. The catalyst has been found to be more active than trimethylsilyl triflate for the above reaction.