49685-65-6

Basic information

• Product Name: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile
• Synonyms: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile
• CAS NO: 49685-65-6
• Molecular Weight: 175.23
• Mol File: 49685-65-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile(49685-65-6)
• EPA Substance Registry System: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile(49685-65-6)

Safety Data

• Hazardous Substances Data: 49685-65-6(Hazardous Substances Data)

Upstream product

• 487-68-3 mesytaldehyde 
• 74-90-8 hydrogen cyanide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 860538-02-9 2-amino-1-mesityl-2-phenylethane-1-one 
• 63809-16-5 (R)-[(S)-Methoxycarbonyl-(2,4,6-trimethyl-phenyl)-methoxy]-(2,4,6-trimethyl-phenyl)-acetic acid methyl ester 
• 63809-18-7 2-Hydroxy-2-(2',4',6'-trimethylphenyl)ethanoic amide 
• 63809-19-8 2,4,6-trimethyl-mandelic acid-methyl ester 
• 1346425-01-1 1-(2,4,6-trimethylbenzyl)pyrrolidine-2-carbonitrile 
• 487-68-3 mesytaldehyde 
• 480-63-7 mesitylenecarboxylic acid 
• 55878-82-5 2,4,6-trimethyl-α-oxobenzeneacetonitrile 

Relevant articles and documents

CO2-Enabled Cyanohydrin Synthesis and Facile Iterative Homologation Reactions**

Thermodynamic and kinetic control of a chemical process is the key to access desired products and states. Changes are made when a desired product is not accessible; one may manipulate the reaction with additional reagents, catalysts and/or protecting groups. Here we report the use of carbon dioxide to accelerate cyanohydrin synthesis under neutral conditions with an insoluble cyanide source (KCN) without generating toxic HCN. Under inert atmosphere, the reaction is essentially not operative due to the unfavored equilibrium. The utility of CO2-mediated selective cyanohydrin synthesis was further showcased by broadening Kiliani–Fischer synthesis under neutral conditions. This protocol offers an easy access to a variety of polyols, cyanohydrins, linear alkylnitriles, by simply starting from alkyl- and arylaldehydes, KCN and an atmospheric pressure of CO2.

Redox-neutral α-cyanation of amines

α-Aminonitriles inaccessible by traditional Strecker chemistry are obtained in redox-neutral fashion by direct amine α-cyanation/N-alkylation or alternatively, α-aminonitrile isomerization. These unprecedented transformations are catalyzed by simple carboxylic acids.