49690-09-7

Basic information

• Product Name: N-tert-Butyl 4-Nitrophenylsulfonamide
• Synonyms: N-tert-Butyl 4-Nitrophenylsulfonamide;4-nitro-N-tert-butylbenzenesulfonamide
• CAS NO: 49690-09-7
• Molecular Formula: C₁₀H₁₄N₂O₄S
• Molecular Weight: 258.2942
• Mol File: 49690-09-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 392.2 °C at 760 mmHg
• Flash Point: 191 °C
• Appearance: /
• Density: 1.282 g/cm³
• Vapor Pressure: 2.34E-06mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-tert-Butyl 4-Nitrophenylsulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyl 4-Nitrophenylsulfonamide(49690-09-7)
• EPA Substance Registry System: N-tert-Butyl 4-Nitrophenylsulfonamide(49690-09-7)

Safety Data

• Hazardous Substances Data: 49690-09-7(Hazardous Substances Data)

Usage

General Description

N-tert-Butyl 4-Nitrophenylsulfonamide is a chemical compound that belongs to the class of sulfonamides, which are known for their antibacterial and antifungal properties. This specific compound consists of a 4-nitrophenylsulfonamide group attached to a tert-butyl group. It is used in various industrial and scientific applications, including as a building block in the synthesis of pharmaceuticals and agrochemicals. The nitro group in the compound provides it with unique properties and reactivity, making it useful in the development of diverse chemical compounds. Additionally, the tert-butyl group enhances its stability and solubility in organic solvents, making it easier to handle in laboratory settings. Overall, N-tert-Butyl 4-Nitrophenylsulfonamide plays a crucial role in the synthesis of valuable chemical compounds and has potential industrial and pharmaceutical applications.

InChI:InChI=1/C10H14N2O4S/c1-10(2,3)11-17(15,16)9-6-4-8(5-7-9)12(13)14/h4-7,11H,1-3H3

Upstream product

• 75-64-9 tert-butylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 24939-24-0 4-aminobenzenesulfonyl chloride 
• 10218-88-9 N-monochloro-t-butylamine 
• 149552-43-2 [N-(nosyl)imino]phenyliodinane 
• 51655-37-9 N-bromo-2-methylpropan-2-amine 
• 2216-51-5 (-)-menthol 
• 1569262-64-1 ethyl N-tert-butyl-4-nitrobenzenesulfonimidate 
• 76-05-1 trifluoroacetic acid 
• 75-75-2 methanesulfonic acid 

Downstream Products

• 6325-93-5 p-nitrobenzenesulfonamide 
• 1569262-64-1 ethyl N-tert-butyl-4-nitrobenzenesulfonimidate 
• 1028253-27-1 N-(4-(tert-butylsulfamoyl)phenyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-28-2 N-(4-(tert-butylsulfamoyl)phenyl)-3-methyl-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-30-6 3-methyl-N-(4-sulfamoylphenyl)-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-29-3 2-(4-(N-tert-butylsulfamoyl)phenylamino)-3,3-dimethylbutanoic acid 
• 915006-33-6 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid [4-tert-butylsulfamoyl-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amide 
• 915006-34-7 4-amino-N-tert-butyl-3-(4,4-dimethyl-cyclohex-1-enyl)-benzenesulfonamide 
• 915006-42-7 4-amino-N-tert-butyl-3-cyclohex-1-enyl-benzenesulfonamide 
• 915006-43-8 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide 
• 209917-48-6 4-amino-N-(dimethylethyl)benzenesulfonamide 

Relevant articles and documents

Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold

Recent reports have highlighted the dual bromodomains of TAF1 (TAF1(1,2)) as synergistic with BET inhibition in cellular cancer models, engendering interest in TAF/BET polypharmacology. Here, we examine structure activity relationships within the BI-2536 PLK1 kinase inhibitor scaffold, previously reported to bind BRD4. We examine binding by this ligand to TAF1(2) and apply structure guided design strategies to discriminate binding to both the PLK1 kinase and BRD4(1) bromodomain while retaining activity on TAF1(2). Through this effort we discover potent dual inhibitors of TAF1(2)/BRD4(1), as well as biased derivatives showing marked TAF1 selectivity. We resolve X-ray crystallographic data sets to examine the mechanisms of the observed TAF1 selectivity and to provide a resource for further development of this scaffold.

Visible-light-mediated, nitrogen-centered radical amination of tertiary alkyl halides under metal-free conditions to form α-tertiary amines

A mild and operationally convenient amino-functionalization of a range of tertiary alkyl halides by reaction with iminoiodinanes (PhINNs) and I2 has been developed. According to the mechanistic experiments described within, the reaction is spec

SNAAP sulfonimidate alkylating agent for acids, alcohols, and phenols 1

Stable, crystalline ethyl N-tert-butyl-4-nitrobenzenesulfonimidate has been prepared in high yield by direct O-ethylation of N-tert-butyl-4- nitrobenzenesulfonamide with iodoethane and silver(I) oxide in dichloromethane. This sulfonimidate directly ethylates various acids to esters; the stronger the acid, the faster it alkylates and in higher yield. It readily ethylates alcohols and phenols to ethers at room temperature in the presence of tetrafluoroboric acid catalyst without molecular rearrangements or racemization. We have defined these reactions as SNAAP alkylations: [substitution, nucleophilic of acids, alcohols and phenols]. The hard sulfonimidate alkylating agent is chemoselective, preferring oxygen > nitrogen > sulfur. The sulfonamide byproduct of alkylation is readily recycled to the sulfonimidate. Georg Thieme Verlag Stuttgart . New York.