49690-09-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
N-tert-Butyl 4-Nitrophenylsulfonamide is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique properties and reactivity contribute to the development of diverse chemical compounds with potential therapeutic and agricultural applications.
Used in Chemical Research:
In the field of chemical research, N-tert-Butyl 4-Nitrophenylsulfonamide is utilized for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique structure and reactivity make it a valuable tool for advancing scientific knowledge and discovering new applications.
Used in Industrial Applications:
N-tert-Butyl 4-Nitrophenylsulfonamide plays a crucial role in various industrial applications, where its stability and solubility in organic solvents are advantageous. Its potential use in the development of new materials and processes can contribute to innovation and progress in various industries.

InChI:InChI=1/C10H14N2O4S/c1-10(2,3)11-17(15,16)9-6-4-8(5-7-9)12(13)14/h4-7,11H,1-3H3

Upstream product

• 75-64-9 tert-butylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 51655-37-9 N-bromo-2-methylpropan-2-amine 
• 149552-43-2 [N-(nosyl)imino]phenyliodinane 
• 10218-88-9 N-monochloro-t-butylamine 
• 24939-24-0 4-aminobenzenesulfonyl chloride 
• 2216-51-5 (-)-menthol 
• 1569262-64-1 ethyl N-tert-butyl-4-nitrobenzenesulfonimidate 
• 76-05-1 trifluoroacetic acid 
• 75-75-2 methanesulfonic acid 

Downstream Products

• 6325-93-5 p-nitrobenzenesulfonamide 
• 1569262-64-1 ethyl N-tert-butyl-4-nitrobenzenesulfonimidate 
• 1028253-29-3 2-(4-(N-tert-butylsulfamoyl)phenylamino)-3,3-dimethylbutanoic acid 
• 1028253-30-6 3-methyl-N-(4-sulfamoylphenyl)-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-28-2 N-(4-(tert-butylsulfamoyl)phenyl)-3-methyl-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-27-1 N-(4-(tert-butylsulfamoyl)phenyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 915006-33-6 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid [4-tert-butylsulfamoyl-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amide 
• 915006-34-7 4-amino-N-tert-butyl-3-(4,4-dimethyl-cyclohex-1-enyl)-benzenesulfonamide 
• 915006-42-7 4-amino-N-tert-butyl-3-cyclohex-1-enyl-benzenesulfonamide 
• 915006-43-8 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide 
• 209917-48-6 4-amino-N-(dimethylethyl)benzenesulfonamide 

Relevant academic research and scientific papers

Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold

Recent reports have highlighted the dual bromodomains of TAF1 (TAF1(1,2)) as synergistic with BET inhibition in cellular cancer models, engendering interest in TAF/BET polypharmacology. Here, we examine structure activity relationships within the BI-2536 PLK1 kinase inhibitor scaffold, previously reported to bind BRD4. We examine binding by this ligand to TAF1(2) and apply structure guided design strategies to discriminate binding to both the PLK1 kinase and BRD4(1) bromodomain while retaining activity on TAF1(2). Through this effort we discover potent dual inhibitors of TAF1(2)/BRD4(1), as well as biased derivatives showing marked TAF1 selectivity. We resolve X-ray crystallographic data sets to examine the mechanisms of the observed TAF1 selectivity and to provide a resource for further development of this scaffold.

BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Visible-light-mediated, nitrogen-centered radical amination of tertiary alkyl halides under metal-free conditions to form α-tertiary amines

A mild and operationally convenient amino-functionalization of a range of tertiary alkyl halides by reaction with iminoiodinanes (PhINNs) and I2 has been developed. According to the mechanistic experiments described within, the reaction is spec

POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.

SNAAP sulfonimidate alkylating agent for acids, alcohols, and phenols 1

Stable, crystalline ethyl N-tert-butyl-4-nitrobenzenesulfonimidate has been prepared in high yield by direct O-ethylation of N-tert-butyl-4- nitrobenzenesulfonamide with iodoethane and silver(I) oxide in dichloromethane. This sulfonimidate directly ethylates various acids to esters; the stronger the acid, the faster it alkylates and in higher yield. It readily ethylates alcohols and phenols to ethers at room temperature in the presence of tetrafluoroboric acid catalyst without molecular rearrangements or racemization. We have defined these reactions as SNAAP alkylations: [substitution, nucleophilic of acids, alcohols and phenols]. The hard sulfonimidate alkylating agent is chemoselective, preferring oxygen > nitrogen > sulfur. The sulfonamide byproduct of alkylation is readily recycled to the sulfonimidate. Georg Thieme Verlag Stuttgart . New York.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

METHOD OF PREPARING 4-(IMIDAZOLE-1-IL)BENZENESULPHONAMIDE DERIVATIVES

Process for the preparation of 4-(imidazol-1-yl)benzenesulfonamide derivatives of formula I, wherein R1 represents optionally substituted aryl or heteroaryl, which comprises treating a compound of formula II, wherein R1 has the same

Phosphonamidic-Sulfonic Mixed Anhydrides: Possible Initial Products in the Base-induced Rearrangement Reactions of N-Phosphinoyl-O-sulfonylhydroxylamines

In PriNH2-ButNH2 competition experiments the behaviour of the two phosphonamidic-sulfonic mixed anhydrides 2 and 7 resembles that of the corresponding hydroxylamine derivatives 1 and 6.