496930-07-5Relevant articles and documents
Linear TMC-95-based proteasome inhibitors
Basse, Nicolas,Piguel, Sandrine,Papapostolou, David,Ferrier-Berthelot, Alexandra,Richy, Nicolas,Pagano, Maurice,Sarthou, Pierre,Sobczak-Thépot, Jo?lle,Reboud-Ravaux, Michele,Vidal, Jo?lle
, p. 2842 - 2850 (2008/02/07)
We have designed and evaluated 45 linear analogues of the natural constrained cyclopeptide TMC-95A. These synthetically less demanding molecules are based on the tripeptide sequence Y-N-W of TMC-95A. Structural variations in the amino acid side chains and
Convenient synthesis of 7′ and 6′-bromo-D-tryptophan and their derivatives by enzymatic optical resolution using D-aminoacylase
Konda-Yamada, Yaeko,Okada, Chiharu,Yoshida, Kiminari,Umeda, Yasuyuki,Arima, Shiho,Sato, Noriko,Kai, Toshitsugu,Takayanagi, Hiroaki,Harigaya, Yoshihiro
, p. 7851 - 7861 (2007/10/03)
Compounds 7′ and 6′-bromo-D-tryptophan (1 and 2) which are important derivatives for the synthesis of the chloropeptin and kistamycin A, respectively, were conveniently synthesized by optical resolution from N-acetyl-7′ and 6′-bromo-DL-tryptophan ((RS)-5 and (RS)-14) using D-aminoacylase.