49696-23-3

Upstream product

• 106-93-4 ethylene dibromide 
• 75-15-0 carbon disulfide 
• 4023-80-7 1-(4-methoxyphenyl)butan-1,3-dione 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 50849-98-4 3,3-dimercapto-1-(4-methoxy-phenyl)-propenone 

Downstream Products

• 137621-86-4 2-(1,3-Dithiolan-2-ylidene)-3-(4-methoxyphenyl)-3-oxopropanal 
• 1245820-59-0 (E)-4-(1,3-dithiolan-2-ylidene)-5-(4-methoxyphenyl)-N,N-dimethyl-5-oxopent-2-enamide 
• 1245820-40-9 (E)-ethyl 4-(1,3-dithiolan-2-ylidene)-5-(4-methoxyphenyl)-5-oxopent-2-enoate 
• 1643578-13-5 2-(1,3-dithiolan-2-ylidene)-1-(4-methoxyphenyl)-3-phenylbutan-1-one 
• 113968-10-8 2-(α-bromo-p-methoxyphenacylidene)-1,3-dithiole 

Relevant academic research and scientific papers

Alternative Palladium-Catalyzed Vinylic C?H Difluoroalkylation of Ketene Dithioacetals Using Bromodifluoroacetate Derivatives

A palladium-catalyzed cross-coupling of α-oxo ketene dithioacetals and bromodifluoroacetate derivatives has been developed for the synthesis of a class of CF2-containing tetra-substituted olefins, which has potential to extend to drug design an

C-H bonds phosphorylation of ketene dithioacetals

C-H bond phosphorylation of ketene dithioacetals was achieved under transition-metal-free or AgNO3 mediated conditions. Synthetic transformations of the coupling product provided promising methods for the construction of highly functionalized p

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.

Iron-catalyzed alkylation of α-oxo ketene dithioacetals

Iron-catalyzed alkylation of internal olefins, that is, α-oxo ketene dithioacetals, was successfully realized by using styrenes as the alkylating reagents. Highly functionalized tetrasubstituted olefins were prepared in moderate to high yields. the Partner Organisations 2014.

Synthesis of densely substituted 1,3-butadienes through acid-catalyzed alkenylations of α-oxoketene dithioacetals with aldehydes

Aldehydes were proved to be viable reagents for implementing alkenylation of α-oxoketene dithioacetals. AlCl3 was found to be the best catalyst. The established reaction opened an avenue to access densely substituted 1,3-butadiene derivatives. The obtained product bears multiple reactive sites that can be converted into various valuable molecules. (Chemical Equation Presented).