49696-23-3

Upstream product

• 106-93-4 ethylene dibromide 
• 50849-98-4 3,3-dimercapto-1-(4-methoxy-phenyl)-propenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 75-15-0 carbon disulfide 
• 4023-80-7 1-(4-methoxyphenyl)butan-1,3-dione 

Downstream Products

• 137621-86-4 2-(1,3-Dithiolan-2-ylidene)-3-(4-methoxyphenyl)-3-oxopropanal 
• 113968-10-8 2-(α-bromo-p-methoxyphenacylidene)-1,3-dithiole 
• 1643578-13-5 2-(1,3-dithiolan-2-ylidene)-1-(4-methoxyphenyl)-3-phenylbutan-1-one 
• 1245820-40-9 (E)-ethyl 4-(1,3-dithiolan-2-ylidene)-5-(4-methoxyphenyl)-5-oxopent-2-enoate 

Relevant academic research and scientific papers

Alternative Palladium-Catalyzed Vinylic C?H Difluoroalkylation of Ketene Dithioacetals Using Bromodifluoroacetate Derivatives

A palladium-catalyzed cross-coupling of α-oxo ketene dithioacetals and bromodifluoroacetate derivatives has been developed for the synthesis of a class of CF2-containing tetra-substituted olefins, which has potential to extend to drug design an

C-H bonds phosphorylation of ketene dithioacetals

C-H bond phosphorylation of ketene dithioacetals was achieved under transition-metal-free or AgNO3 mediated conditions. Synthetic transformations of the coupling product provided promising methods for the construction of highly functionalized p

Synthesis of densely substituted 1,3-butadienes through acid-catalyzed alkenylations of α-oxoketene dithioacetals with aldehydes

Aldehydes were proved to be viable reagents for implementing alkenylation of α-oxoketene dithioacetals. AlCl3 was found to be the best catalyst. The established reaction opened an avenue to access densely substituted 1,3-butadiene derivatives. The obtained product bears multiple reactive sites that can be converted into various valuable molecules. (Chemical Equation Presented).

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.

Iron-catalyzed alkylation of α-oxo ketene dithioacetals

Iron-catalyzed alkylation of internal olefins, that is, α-oxo ketene dithioacetals, was successfully realized by using styrenes as the alkylating reagents. Highly functionalized tetrasubstituted olefins were prepared in moderate to high yields. the Partner Organisations 2014.