497069-12-2Relevant academic research and scientific papers
BENZOATE COMPOUND
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, (2022/01/04)
The present invention provides a benzoic acid ester compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. A compound represented by the formula (I) or a salt thereof has an enteropeptidase inhibitory effect and is useful as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like: [in the formula, each symbol is as defined in the specification].
FUSED HETEROCYCLIC COMPOUND
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Paragraph 0461-0462, (2018/04/12)
The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present
Synthesis of organometallic poly(dendrimer)s by macromonomer polymerization: effect of dendrimer size and structural rigidity on the polymerization efficiency
Cheung, Siu-Yin,Chow, Hak-Fun,Ngai, To,Wei, Xiaoling
supporting information; experimental part, p. 2278 - 2288 (2009/10/23)
Two series of first to third generation (G1-G3) oligoether dendrimers, one hearing a shorter spacer chain (C-O) and the other having a longer spacer branch (C-C-C-O) were prepared. Both series of compounds, containing two reactive C≡CH moieties on the dendrimer surface, were used as macromonomers and copolymerized with trans-[Pt(PEt3)2Cl2] to form organometallic poly(dendrimer)s by an outer-sphere-outer-sphere connection strategy. It was found that concentration of monomer used in the polymerization, the dendrimer generation, and, most strikingly, the length of the spacer were key factors that determined the polymerization efficiency. Hence, the structurally more rigid and compact C-O linked dendrimers formed poly(dendrimer)s with a higher degree of polymerization than the structurally less rigid and more bulky C-C-C-O dendrimers. This result was due to the higher tendency to form cyclic oligomers in the latter series of compounds. In addition, the differences in the polymerization efficiency among the three generations of dendrimers could be explained by the gradual decrease of reactive functional group density on the dendrimer surface.
Invertible amphiphilic polymers
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Page/Page column 6; 7, (2010/11/29)
Amphiphilic monomeric compounds and corresponding homopolymers and copolymers capable of assembly and invertible configuration in introduction to and change in fluid medium.
Comparison of facially amphiphilic biaryl dendrimers with classical amphiphilic ones using protein surface recognition as the tool
Klaikherd, Akamol,Sandanaraj, Britto S.,Vutukuri, Dharma Rao,Thayumanavan
, p. 9231 - 9237 (2007/10/03)
Facially amphiphilic biaryl dendrimers are compared with the more classical benzyl ether amphiphilic dendrimers for molecular recognition, using protein binding as the probe. The protein used for the proposed study is chymotrypsin (ChT). A generation-depe
Homopolymer micelles in heterogeneous solvent mixtures
Basu, Subhadeep,Vutukuri, Dharma Rao,Thayumanavan
, p. 16794 - 16795 (2007/10/03)
Amphiphilic homopolymers containing a hydrophilic and a hydrophobic functionality in each monomer unit have been shown to form polar or apolar containers depending on the solvent environment. When presented with a mixture of solvents, these polymeric cont
Invertible amphiphilic homopolymers
Basu, Subhadeep,Vutukuri, Dharma Rao,Shyamroy, Subarana,Sandanaraj, Britto S.,Thayumanavan
, p. 9890 - 9891 (2007/10/03)
Stimuli-responsive polymers and assemblies are viable candidates for the so-called "smart" materials. In this communication, we report a new class of amphiphilic homopolymers that forms micelle-like structures in polar solvents and inverted micelle-like structures in apolar solvents. We demonstrate that these superstructures are the result of the changes in the molecular-level conformations in the monomer. Copyright
A mild deprotection strategy for allyl-protecting groups and its implications in sequence specific dendrimer synthesis
Vutukuri, Dharma Rao,Bharathi, Pandi,Yu, Zhouying,Rajasekaran, Karthik,Tran, My-Huyen,Thayumanavan
, p. 1146 - 1149 (2007/10/03)
A mild deprotection strategy for allyl ethers under basic conditions in the presence of a palladium catalyst is described. Under these conditions, aryl allyl ethers can be cleaved selectively in the presence of alkyl allyl ethers. These conditions are also effective in the deprotection of allyloxycarbonyl groups. The utility of the current methodology in sequence specific dendrimer synthesis is demonstrated.
