49713-47-5

Usage

Uses

Used in Pharmaceutical Synthesis:
4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLIC ACID is used as a key building block for the synthesis of various pharmaceuticals and organic compounds, leveraging its unique structure and reactivity to create novel and effective medications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLIC ACID is utilized for its potential antiviral and anticancer activities, serving as a subject of study to explore its therapeutic capabilities and further our understanding of its medicinal properties.
Used in the Development of Synthetic Methods:
4-HYDROXY-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLIC ACID contributes to the advancement of new synthetic methods, capitalizing on its chemical properties to enhance the efficiency and effectiveness of organic synthesis processes.
Used in Material Science:
Its role in material science is highlighted by its application in the development of new materials, where its structural and reactive attributes are employed to innovate and improve material properties across various industries.

InChI:InChI=1/C11H6F3NO3/c12-11(13,14)5-1-2-8-6(3-5)9(16)7(4-15-8)10(17)18/h1-4H,(H,15,16)(H,17,18)

Upstream product

• 71083-01-7 ethyl 4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate 
• 455-14-1 4-trifluoromethylphenylamine 
• 49713-39-5 diethyl 2-(((4-(trifluoromethyl)phenyl)amino)methylene)malonate 

Downstream Products

• 49713-56-6 4-chloro-6-(trifluoromethyl)quinoline 
• 49713-51-1 C₁₀H₆F₃NO 
• 1236058-25-5 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 4-oxoquinoline-3-carboxamides derivatives as potent anti-fibrosis agents

Thirty-one 4-oxoquinoline-3-carboxamides derivatives were synthesized and evaluated for their anti-fibrotic activities by the inhibition of TGF-β1-induced total collagen accumulation and anti-inflammatory activities by the inhibition of LPS-stimulated TNF-α production. Among them, three compounds (10a, 10l and 11g) exhibited potent inhibitory effects on both TGF-β1-induced total collagen accumulation and LPS-stimulated TNF-α production. Furthermore, oral administrations of 10l at a dose of 20 mg/kg/day for 4 weeks effectively alleviated lung inflammation and injury, and decreased lung collagen accumulation in bleomycin-induced pulmonary fibrosis model. Histopathological evaluation of lung tissue confirmed 10l as a potential, orally active agent for the treatment of pulmonary fibrosis.

Structural optimization of quinolon-4(1 H)-imines as dual-stage antimalarials: Toward increased potency and metabolic stability

Discovery of novel effective and safe antimalarials has been traditionally focused on targeting erythrocytic parasite stages that cause clinical symptoms. However, elimination of malaria parasites from the human population will be facilitated by intervent

Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo

Quinolone-3-carboxamides 11 bearing at position 5, 6, 7, or 8 diverse substituents such as halides, alkyl, aryl, alkoxy, and aryloxy groups differing in their steric/electronic properties, were prepared. The new compounds were tested in vitro for CB1 and