497224-06-3Relevant academic research and scientific papers
BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF
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, (2016/02/29)
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-me
Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety
Seto, Masaki,Aikawa, Katsuji,Miyamoto, Naoki,Aramaki, Yoshio,Kanzaki, Naoyuki,Takashima, Katsunori,Kuze, Yoji,Iizawa, Yuji,Baba, Masanori,Shiraishi, Mitsuru
, p. 2037 - 2048 (2007/10/03)
Chemical modification has been performed on an orally bioavailable and potent CCR5 antagonist, sulfoxide compound 4, mainly focusing on replacement of the [6,7]-fused 1-benzazepine nucleus. We designed, synthesized, and evaluated the biological activities
