497250-93-8

Basic information

• Product Name: 1,3-Dioxolane, 2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-
• CAS NO: 497250-93-8
• Molecular Formula: C11H10BrCl3O2
• Molecular Weight: 360.462
• Mol File: 497250-93-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-(497250-93-8)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-(497250-93-8)

Safety Data

• Hazardous Substances Data: 497250-93-8(Hazardous Substances Data)

Upstream product

• 4362-40-7 5-chloromethyl-2,2-dimethyl-1,3-dioxolane 
• 2631-72-3 2,4-dichlorophenacyl bromide 

Downstream Products

• 61397-56-6 (+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate 
• 61397-56-6 trans-[2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate 

Relevant articles and documents

Stereoselective Syntheses of Both Enantiomers of Ketoconazole from (R)- and (S)-Epichlorohydrin

Stereoselective syntheses of both enantiomers of ketoconazole (1) from commercially available (R)- or (S)-epichlorohydrin has been developed.The key-step of syntheses involves the selective substitution of the methylene chlorine atom by benzoate on a mixture of (2S,4R)-14a and (2R,4R)-15a or of their enentiomers, followed by crystalization of the corresponding cis-benzoates, (2R,4R)-18 or (2S,4S)-18, from which (+)- or (-)-1 were obtained as described for (+/-)-1.The ee's of (+)- and (-)-ketocanazole were determined by HPLC on the CSP Chiracel OD-H.