4362-40-7

Basic information

• Product Name: 4-(CHLOROMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
• Synonyms: 4-(chloromethyl)-2,2-dimethyl-3-dioxolane;4-chloromethyl-2,2-dimethyl-3-dioxolane;4-(CHLOROMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;4-(CHLOROMETHYL)-2,2-DIMETHYL-1,3- DIOXOLANE 99%;2,2-Dimethyl-4-(chloromethyl)-1,3-dioxolane;4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane,99%
• CAS NO: 4362-40-7
• Molecular Formula: C₆H₁₁ClO₂
• Molecular Weight: 150.6
• EINECS: 224-452-5
• Product Categories: Organic Building Blocks;Oxygen Compounds;Protected Alcohols/Phenols
• Mol File: 4362-40-7.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 156-158 °C(lit.)
• Flash Point: 128 °F
• Appearance: /
• Density: 1.063 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.8mmHg at 25°C
• Refractive Index: n20/D 1.434(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(CHLOROMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE(4362-40-7)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE(4362-40-7)

Safety Data

• Hazard Codes: T
• Statements: 10-25
• Safety Statements: 16-23-26-36/37/39
• RIDADR: UN 1992 3/PG 3
• WGK Germany: 3
• RTECS: JH6950000
• Hazardous Substances Data: 4362-40-7(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to light yellow liquid

Uses

Different sources of media describe the Uses of 4362-40-7 differently. You can refer to the following data:
1. 4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is used in biosynthetic preparations.
2. 4-Chloromethyl-2,2-dimethyl-1,3-dioxolane may be used in the preparation of 2,2-dimethyl-4-methylene-1,3-dioxolane via dehydrochlorination.

Synthesis Reference(s)

Canadian Journal of Chemistry, 44, p. 1331, 1966 DOI: 10.1139/v66-199

General Description

4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is a ketal that can be synthesized by the reaction of 3-chloro-propane-1,2-diol (3-MCPD) with acetone in the presence of p-toluene sulfonic acid.

InChI:InChI=1/C6H11ClO2/c1-6(2)8-4-5(3-7)9-6/h5H,3-4H2,1-2H3/t5-/m1/s1

Upstream product

• 67-64-1 acetone 
• 106-89-8 epichlorohydrin 
• 96-24-2 3-monochloro-1,2-propanediol 
• 116-11-0 2-Methoxypropene 
• 77-76-9 2,2-dimethoxy-propane 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 

Downstream Products

• 19358-05-5 2,2-dimethyl-4-methylidene-1,3-dioxolane 
• 52813-61-3 bis((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)amine 
• 22195-47-7 4-aminomethyl-2,2-dimethyl[1,3]dioxolane 
• 138852-37-6 rac-2,3-O-isopropylideneglycerol-1-diphenylphosphane 
• 4288-84-0 1-chloro-3-isopropoxypropan-2-ol 
• 78925-49-2 3-chloro-2-isopropoxy-propan-1-ol 
• 98760-27-1 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane 
• 497250-93-8 (+/-)-2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane 
• 554-10-9 3-iodo-propane-1,2-diol 
• 64445-12-1 2-(4-Isobutyl-phenyl)-propionic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 91540-06-6 4-benziloyloxy-1-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)piperidine 
• 64445-11-0 Hydroxy-phenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 91614-23-2 Diphenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 91522-56-4 Cyclohexyl-hydroxy-phenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 

Relevant articles and documents

Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

Sigma receptors (SRs) are recognized as valuable targets for the treatment of neurodegenerative disorders. A series of novel SRs ligands were designed by combining key pharmacophoric amines (i.e., benzylpiperidine or benzylpiperazine) with new 1,3-dithiolane-based heterocycles and their bioisosters. The new compounds exhibited a low nanomolar affinity for sigma-1 and sigma-2 receptors. Five selected compounds were evaluated for their neuroprotective capacity on SH-SY5Y neuroblastoma cell line. They were able to counteract the neurotoxicity induced by rotenone, oligomycin and NMDA. Competition studies with PB212, a S1R antagonist, confirmed the involvement of S1R in neuroprotection from the oxidative stress induced by rotenone. Electrophysiological experiments performed on cortical neurons in culture highlighted the compounds ability to reduce NMDA-evoked currents, suggesting a negative allosteric modulator activity toward the NMDA receptor. Altogether these results qualify our novel dithiolane derivatives as potential agents for fighting neurodegeneration.

Containing sulfide, N-cyano-sulfur (sulfone) imine structure substituted pyrazole carboxamides double-amide derivatives and process for their preparation and use

The invention provides a double amide derivative containing a sulfur ether and N-sulfur cyano (sulphone) imine structure and replacing pyrazolecarboxamide and a preparing method and purpose thereof, and relates to double amide derivatives containing the pyrazolecarboxamide. The double amide derivative containing the pyrazolecarboxamide has a chemical structure general formula as shown in the map I. The structure general formula and the synthetic method of the double amide derivative and the purpose for being used as insecticides, antiseptics, a plant virus resistance agent and a plant activator are disclosed. The double amide derivative containing the sulfur ether and N-sulfur cayano (sulphone) imine structure and replacing the pyrazolecarboxamide can be mixed with auxiliaries or synergists which are acceptable in agriculture to form a processing technology to be used for preparing the insecticides, the antiseptics, the plant virus resistance agent and the plant activator. The invention further discloses the purpose and preparing method of the double amide derivative containing the sulfur ether and N-sulfur cyano (sulphone) imine structure and replacing the pyrazolecarboxamide combining with commodity insecticides, commodity antiseptics, commodity plant virus resistance agents and commodity plant activators to be used for preventing and curing plant diseases, insect pests, virus diseases in agriculture, forestry and horticulture.

Catalytic conversion of epoxides to 1,3-dioxolanes with phosphomolybdic acid (PMA) in solution and under solvent-free conditions

The fast and efficient conversion of epoxides into 2,2-dimethyl-1,3- dioxolanes was studied with catalytic amounts of phosphomolybdic acid (PMA) (0.1-0.2 mol %) at room temperature in solution and under solvent-free conditions. The products were obtained in high to excellent yields within 1-2 min. Copyright Taylor & Francis Group, LLC.