4974-57-6

Basic information

• Product Name: P-NITROPHENYLGLYOXAL
• Synonyms: 2-(4-NITROPHENYL)-2-OXOACETALDEHYDE;4-NITROPHENYLGLYOXAL;P-NITROPHENYLGLYOXAL;1-(4-Nitrophenyl)glyoxal;4-Nitro-α-oxobenzeneacetaldehyde;2-(4-nitrophenyl)-2-oxo-ethanal;2-keto-2-(4-nitrophenyl)acetaldehyde
• CAS NO: 4974-57-6
• Molecular Formula: C₈H₅NO₄
• Molecular Weight: 179.13
• Mol File: 4974-57-6.mol
• Article Data: 57

Chemical Properties

• Melting Point: 96-98℃
• Boiling Point: 321.4 °C at 760 mmHg
• Flash Point: 163 °C
• Appearance: Cream/Crystalline Powder
• Density: 1.376 g/cm³
• Vapor Pressure: 0.000298mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: P-NITROPHENYLGLYOXAL(CAS DataBase Reference)
• NIST Chemistry Reference: P-NITROPHENYLGLYOXAL(4974-57-6)
• EPA Substance Registry System: P-NITROPHENYLGLYOXAL(4974-57-6)

Safety Data

• Hazardous Substances Data: 4974-57-6(Hazardous Substances Data)

Usage

Uses

As important industrial compounds and are mainly used as solvents. A new method for arginase assay

InChI:InChI=1/C8H5NO4/c10-5-8(11)6-1-3-7(4-2-6)9(12)13/h1-5H

Upstream product

• 100-19-6 (4-nitrophenyl)ethanone 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 100-13-0 4-nitrostyrene 
• 4996-22-9 4-nitrophenylglyoxal 
• 110944-98-4 2-iodo-1-(4-nitrophenyl)ethanone 
• 1044637-41-3 N-(2-oxo-2-(p-nitrophenyl)ethoxy)phthalimide 
• 18731-47-0 1-(4-nitrophenyl)-2-nitroethanol 
• 1439-43-6 1-(4-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 99-81-0 4-Nitrophenacyl bromide 
• 75295-87-3 (4-nitro-phenyl)-glyoxal-2-(triphenylphosphoranylidene-hydrazone) 
• 91736-68-4 3-(4-nitrophenyl)-2-propoxy-1-(4-nitrophenylmethyl)-1,2-dihydroquinoxaline 
• 91736-70-8 3-(4-nitrophenyl)-1-benzyl-2-propoxy-1,2-dihydroquinoxaline 

Downstream Products

• 63104-97-2 (E)-4-(4-nitrophenyl)-4-oxobut-2-enoic acid 
• 5541-64-0 2-(4-nitro-phenyl)-quinoxaline 
• 123488-74-4 2-Hydroxy-1-(4-nitro-phenyl)-2-(pyridin-2-ylamino)-ethanone 
• 1111072-46-8 3,3'-[2-(4-nitrophenyl)-2-oxoethylidene]bis[4-hydroxy-2H-1-benzopyran-2-one] 
• 1063626-99-2 1,3-dimethyl-5-(2-(4-nitrophenyl)-2-oxoethylidene)-pyrimidine-2,4,6-trione 
• 1246470-85-8 C₁₂H₈N₄O₃ 
• 1227680-25-2 2-cyclohexylamino-3-(4-nitro-benzoyl)-furo[3,2-c]chromen-4-one 
• 1227680-30-9 2-t-butylamino-3-(4-nitro-benzoyl)-furo[3,2-c]chromen-4-one 
• 4996-22-9 4-nitrophenylglyoxal 
• 1334231-24-1 4-(4-nitrophenyl)-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione 
• 1375459-87-2 1-(4-nitrophenyl)-2,2-di(1H-indole-3-yl)ethanone 
• 1375459-89-4 1-(4-nitrophenyl)-2,2-di(benzotriazol-1-yl)ethanone 
• 1389334-37-5 C₁₉H₁₈N₂O₄ 
• 1404111-76-7 3-(4-nitrophenyl)-7,8-dihydrocinnolin-5(6H)-one 

Relevant articles and documents

A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding

In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89–115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure–activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.

Catalytic Asymmetric Darzens-Type Epoxidation of Diazoesters: Highly Enantioselective Synthesis of Trisubstituted Epoxides

Highly enantioselective Darzens-type epoxidation of diazoesters with glyoxal derivatives was accomplished using a chiral boron–Lewis acid catalyst, which facilitated asymmetric synthesis of trisubstituted α,β-epoxy esters. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in high yield (up to 99 %) with excellent enantio- and diastereoselectivity (up to >99 % ee and >20:1 dr, respectively). The synthetic potential of this method was illustrated by conversion of the products to various compounds such as epoxy γ-butyrolactone, tertiary β-hydroxy ketone and epoxy diester.

Antiproliferative Activity of 2-Aroyland 2-Heteroyl-1,1,3,3-Tetracyanoprop-2-en-1-ides

The influence of previously synthesized 2-aroyl-1,1,3,3-tetracyanoprop-2-en-1-ides on the growth of conditionally normal and tumor cells was studied in continuation of a search for new anticancer drugs. Cytotoxicities of the compounds were studied with respect to human tumor cell lines from the ATCC. All compounds were ineffective against melanoma and lung and ovary cancer cell lines and exhibited moderate activity in the other cases. The tested compounds exhibited highly selective effects because they were safe for conditionally normal skin fibroblasts.