49745-68-8

Upstream product

• 67-56-1 methanol 
• 90852-99-6 ptelatoside-B 
• 90899-20-0 4-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl]-styrene 
• 2628-16-2 p-acetoxystyrene 
• 99-93-4 4-Hydroxyacetophenone 
• 93453-79-3 1-(4-hydroxyphenyl)ethanol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2628-17-3 4-Vinylphenol 
• 123-07-9 4-Ethylphenol 
• 108-24-7 acetic anhydride 

Downstream Products

• 1210825-33-4 ethyl (2S)-2-[(1S)-1-(4-hydroxyphenyl)ethoxy]propanoate 
• 1210825-35-6 ethyl (2S)-2-[(1R)-1-(4-hydroxyphenyl)ethoxy]propanoate 

Relevant academic research and scientific papers

An Iridium Catalytic System Compatible with Inorganic and Organic Nitrogen Sources for Dual Asymmetric Reductive Amination Reactions

Asymmetric reductive amination (ARA) is one of the most promising methods for the synthesis of chiral amines. Herein we report our efforts on merging two ARA reactions into a single-step transformation. Catalyzed by a complex formed from iridium and a steric hindered phosphoramidite, readily available and inexpensive aromatic ketones initially undergo the first ARA with ammonium acetate to afford primary amines, which serve as the amine sources for the second ARA, and finally provide the enantiopure C2-symmetric secondary amine products. The developed process competently enables the successive coupling of inorganic and organic nitrogen sources with ketones in the same reaction system. The Br?nsted acid additive plays multiple roles in this procedure: it accelerates the formation of imine intermediates, minimizes the inhibitory effect of N-containing species on the iridium catalyst, and reduces the primary amine side products.

Silica-supported KHSO4: An efficient system for activation of aromatic terminal olefins

Potassium hydrogen sulfate adsorbed on chromatography-grade silica gel activates electron-rich aromatic terminal olefins towards nucleophilic attack at the benzylic position by alcohols. Temperature plays a crucial role and facilitates suppressing nucleophilic reaction in favor of dimerization of the terminal olefin. Georg Thieme Verlag Stuttgart - New York.

Derivatized polyhydroxystyrenes with a novolak type structure and processes for preparing the same

A process for preparing derivatized poly(4-hydroxystryrene) having a novolak type structure which comprises the steps of (i) supplying a solution of methanol containing 4-hydroxyphenylmethylcarbinol, (ii) subjecting said solution to an acid catalyzed displacement reaction for a sufficient period of time and under suitable conditions of temperature and pressure to convert substantially all of said carbinol to 4-hydroxyphenylmethylcarbinol methyl ether in solution, (iii) polymerizing said ether containing solution in the presence of a suitable acid catalyst for a sufficient period of time and under suitable conditions of temperature and pressure to form a novolak type polymer. New compositions of matter which comprise the derivatized poly(4-hydroxystyrene) prepared in the above manner and which have application in the electronic chemicals market such as in a photoresist composition, and in other areas such as in varnishes, printing inks, epoxy resins, copying paper, tackifiers for rubber, crude oil separators, and the like.

Development of a general Pd(II)-catalyzed intermolecular hydroalkoxylation reaction of vinylphenols by using a sacrificial alcohol as the hydride source

A general hydroalkoxylation of vinylphenols has been successfully developed wherein primary, secondary, and tertiary alcohols can be used as nucleophiles. The key conceptual breakthrough is the use of sec-phenethyl alcohol at relatively low concentrations as the sacrificial alcohol to undergo oxidation and provide the proposed Pd-H intermediate.

Synthesis of polysubstituted bicyclo[3.3.1]nonane-3,7-diones from cyclohexa-2,5-dienones and dimethyl 1,3-acetonedicarboxylate

Oxidation of polysubstituted phenols with phenyliodonium diacetate gives cyclohexa-2,5-dienones, which on reaction with dimethyl 1,3-acetonedicarboxylate afford double-Michael-addition derivatives, whose hydrolysis and decarboxylation provides polysubstituted bicyclo[3.3.1]nonane-3,7-diones. For steric and/or electronic reasons, the Michael reaction only works with 3,5-unsubstituted or 3-substituted cyclohexa-2,5-dienones, if the substituent is not an electron-releasing or a good electron-withdrawing group. Hydrolysis and decarboxylation of the double-Michael adducts from 2,4,4- or 2,4,4,6-substituted cyclohexa-2,5-dienones gives only products of partial hydrolysis and decarboxylation, which exist exclusively in the enol form. (C) 2000 Elsevier Science Ltd.

Optically active benzene derivatives and process for preparation thereof

Disclosed are novel optically active benzene derivatives represented by the formula (I): STR1 wherein R represents an alkyl or alkoxyalkyl group having 1 to 20 carbon atoms, which group may contain a halogen; Z represents a hydrogen atom or a halogen atom

ISOLATION AND STRUCTURES OF TWO NEW p-HYDROXYSTYRENE GLYCOSIDES, PTELATOSIDE-A AND PTELATOSIDE-B FROM BRACKEN, PTERIDIUM AQUILINUM VAR. LATIUSCULUM, AND SYNTHESIS OF PTELATOSIDE-A

Two new p-hydroxystyrene glycosides, ptelatoside-A and ptelatoside-B were isolated from the carcinogenic fraction of aqueous extracts of bracken, Pteridium aquilinum var. latiusculum, and their structures were established to be p-β-primeverosyloxystyrene and p-β-neohesperidosyloxystyrene, respectively by chemical and spectral means.A synthesis of ptelatoside-A was achieved.