49769-49-5

Upstream product

• 49769-48-4 3-formyl-7-(thien-2-ylacetamido)-2-cephem-4-carboxylic acid 
• 908093-98-1 diazodiphenylmethane 

Downstream Products

• 61225-25-0 (6R)-3-((Ξ)-1-hydroxy-propyl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 55243-95-3 (6R)-3-((Ξ)-1-hydroxy-ethyl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 61282-47-1 (6R)-3-((Ξ)-1-benzoyloxy-ethyl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 55243-91-9 (6R)-3-acetyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 61225-19-2 (6R)-3-acetyl-7t-amino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 57988-32-6 benzhydryl 3-difluoromethyl-7-(thien-2-ylacetamido)-2-cephem-4-carboxylate 
• 55243-79-3 (6R)-3-[1,3]dioxolan-2-yl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 55243-79-3 (6R)-3-[1,3]dioxolan-2-yl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

7-Acylamino-3-acyl-2(or 3)cephems

Intermediate C-3 1-hydroxyalkyl or 1-hydroxyarylalkyl cephems, prepared by reacting Grignard reagents at low temperature with 3-formyl-2-cephem compounds, are oxidized to the corresponding 7-acylamino-3-acyl-2(or 3)cephem-4-carboxylic acids and esters thereof, which are useful as antibiotics or as intermediates in preparing antibiotic substances.

Substituted sulfonylacetamido cephalosporins

Cephalosporin compounds having various substituted sulfonylacetamido groups at position 7 have been prepared and have antibacterial activity.