55243-95-3

Upstream product

• 49769-49-5 benzhydryl 3-formyl-7β-(thiophen-2-yl-acetamido)-ceph-2-em-4-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 55331-32-3 (6R)-3-formyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 61225-19-2 (6R)-3-acetyl-7t-amino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 
• 55243-92-0 (6R)-3-acetyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 55243-91-9 (6R)-3-acetyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Cephalosporins having a metaloxy group in 3-substituent

Antibacterial cephalosporins of the formula STR1 wherein Acyl is an acyl group; R is a hydrogen or methoxy, R1 is a hydrocarbyl group containing 1 to 8 carbon atoms; R2 is a hydrogen, alkali metal, alkaline earth metal, halo-alkaline

7-Acylamino-3-acyl-2(or 3)cephems

Intermediate C-3 1-hydroxyalkyl or 1-hydroxyarylalkyl cephems, prepared by reacting Grignard reagents at low temperature with 3-formyl-2-cephem compounds, are oxidized to the corresponding 7-acylamino-3-acyl-2(or 3)cephem-4-carboxylic acids and esters thereof, which are useful as antibiotics or as intermediates in preparing antibiotic substances.