61225-25-0Relevant academic research and scientific papers
SYNTHESIS AND REACTION OF C(3)-PROPYN-1'-OL CEPHEM
Spry, Douglas O.,Bhala, Anita R.
, p. 1799 - 1806 (2007/10/02)
Cephalosporin-C(3)-allenes, propenes, acyl pyrazoles, pyrazoles and isoxazoles can be synthesized from the C(3)-propyn-1'-ol cephem 2.
7-Acylamino-3-acyl-2(or 3)cephems
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, (2008/06/13)
Intermediate C-3 1-hydroxyalkyl or 1-hydroxyarylalkyl cephems, prepared by reacting Grignard reagents at low temperature with 3-formyl-2-cephem compounds, are oxidized to the corresponding 7-acylamino-3-acyl-2(or 3)cephem-4-carboxylic acids and esters thereof, which are useful as antibiotics or as intermediates in preparing antibiotic substances.
