49769-86-0

Upstream product

• 67-56-1 methanol 
• 13612-34-5 2-(2,5-dimethylphenyl)acetic acid 
• 186581-53-3 diazomethane 

Downstream Products

• 49769-83-7 dimethyl 2-(2,5-dimethylphenyl)malonate 
• 433230-57-0 (2,5-dimethylphenyl)acetaldehyde 
• 1612882-17-3 C₁₇H₁₆OS₂ 
• 1612882-27-5 C₁₇H₁₈OS₂ 
• 1612882-34-4 C₁₁H₁₆O 
• 1612882-43-5 C₁₁H₁₅I 

Relevant academic research and scientific papers

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

Preparation method of carboxylic ester compound

The invention relates to a preparation method of a carboxylic ester compound, which comprises the following steps: reacting carboxylic acid with methanol in air under the catalysis of nitrite to obtain an ester compound, the preparation method disclosed by the invention has the advantages of rich raw material sources, cheap and easily available catalyst, mild reaction conditions, simplicity and convenience in operation and the like, a series of fatty carboxylic acids can be modified with high yield, and particularly, the traditional esterification method is generally not suitable for esterification of drug molecules. By utilizing the method, a series of known drug molecules can be modified, so that a shortcut is provided for discovering new drug molecules.

A straightforward organocatalytic alkylation of 2-arylacetaldehydes: An approach towards bisabolanes

A highly stereoselective organocatalytic aalkylation of 2-arylacetaldehydes with a commercially available carbenium tetrafluoroborate is described. The stereoselective alkylation was carried out in acetonitrile/ water, under air in the presence of a commercially available imidazolidinone (MacMillan's catalyst). Key intermediates for the synthesis of bisabolanes were obtained through a simple chemistry. In particular a direct, enantioselective and facile synthesis of (R)-(-)-curcumene is described.