497838-06-9

Upstream product

• 1896-62-4 (E)-benzalacetone 
• 623-47-2 propynoic acid ethyl ester 
• 914359-54-9 ethyl (5E)-4-hydroxy-4-methyl-6-phenylhex-5-en-2-ynoate 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 908254-60-4 ethyl 6-(N-benzyloxycarbonyl)amino-4-methyl-6-phenyl-(4Z)-hexen-2-ynoate 

Relevant academic research and scientific papers

Efficient synthesis of 1,3,5-trisubstituted (pyrrol-2-yl)acetic acid esters via dual nucleophilic reactions of sulfonamides or carbamate with 4-trimethyl-siloxy-(5E)-hexen-2-ynoates: Lewis acid catalyzed SN1 and intramolecular Michael addition

Carbamates or sulfonamides have proven to regioselectively attack 2-propynyl-allyl hybrid cations, generated by the action of TMSOTf on 4-(trimethylsioxy)hex-5-en-2-ynoates, to afford conjugated 6-aminohex-4-en-2- ynoates in which an intramolecular amino-

Lewis acid-catalyzed nucleophilic substitutions of propargylic and allylic silyl ethers with enol silyl ethers

(Matrix presented) Nucleophilic reactions of various enol silyl ethers with carbocation species generated from propargyl silyl ethers by the action of a Lewis acid have been developed. The present method is highly useful for the introduction of allenic or