497959-01-0

Basic information

• Product Name: Quinoline, 1-[(4-chlorophenyl)sulfonyl]-1,2,3,4-tetrahydro-2-[[(trimethylsilyl)oxy]meth yl]-
• CAS NO: 497959-01-0
• Molecular Formula: C19H24ClNO3SSi
• Molecular Weight: 410.009
• Mol File: 497959-01-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Quinoline, 1-[(4-chlorophenyl)sulfonyl]-1,2,3,4-tetrahydro-2-[[(trimethylsilyl)oxy]meth yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 1-[(4-chlorophenyl)sulfonyl]-1,2,3,4-tetrahydro-2-[[(trimethylsilyl)oxy]meth yl]-(497959-01-0)
• EPA Substance Registry System: Quinoline, 1-[(4-chlorophenyl)sulfonyl]-1,2,3,4-tetrahydro-2-[[(trimethylsilyl)oxy]meth yl]-(497959-01-0)

Safety Data

• Hazardous Substances Data: 497959-01-0(Hazardous Substances Data)

Upstream product

• 957467-72-0 2-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-quinoline 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 46185-24-4 1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 63430-96-6 1,2,3,4-tetrahydroquinolin-2-ylmethanol 
• 93-10-7 quinoline-2-carboxylic acid 

Downstream Products

• 497959-02-1 [1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl]-methanol 
• 497959-05-4 carbonic acid 1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-ylmethyl ester 4-nitro-phenyl ester 

Relevant articles and documents

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors

γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther