497959-01-0

Upstream product

• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 46185-24-4 1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 63430-96-6 1,2,3,4-tetrahydroquinolin-2-ylmethanol 
• 93-10-7 quinoline-2-carboxylic acid 
• 957467-72-0 2-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-quinoline 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 497959-05-4 carbonic acid 1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-ylmethyl ester 4-nitro-phenyl ester 
• 955033-95-1 (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol 

Relevant academic research and scientific papers

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

The development of a novel series of tetrahydroquinoline-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors

γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD ther