955033-95-1

Basic information

• Product Name: (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol
• Synonyms: (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol
• CAS NO: 955033-95-1
• Molecular Weight: 337.827
• Mol File: 955033-95-1.mol

Chemical Properties

• CAS DataBase Reference: (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol(955033-95-1)
• EPA Substance Registry System: (R)-(1-((4-chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol(955033-95-1)

Safety Data

• Hazardous Substances Data: 955033-95-1(Hazardous Substances Data)

Upstream product

• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 63430-96-6 1,2,3,4-tetrahydroquinolin-2-ylmethanol 
• 93-10-7 quinoline-2-carboxylic acid 
• 497959-01-0 1-(4-chloro-benzenesulfonyl)-2-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-quinoline 
• 957467-72-0 2-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-quinoline 
• 497959-02-1 [1-(4-chloro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl]-methanol 

Relevant articles and documents

Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π–π Interaction**

The non-noble metal-catalyzed asymmetric hydrogenation of N-heteroaromatics, quinolines, is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asymmetric hydrogenation of quinolines, affording high yields and enantioselectivities (up to 97 % ee). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which is competitive with the activity of most effective noble metal catalysts for this reaction. The precise regulation of the enantioselectivity were ensured by a π–π interaction.

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

The development of a novel series of tetrahydroquinoline-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.