4980-68-1

Upstream product

• 677-21-4 1,1,1-trifluoropropylene 
• 71-43-2 benzene 
• 201230-82-2 carbon monoxide 
• 180286-97-9 9-(3-phenylpropyl)-9-borabicyclo[3.3.1]nonane 
• 17376-04-4 2-phenethyl iodide 
• 122-78-1 phenylacetaldehyde 
• 1895-39-2 sodium chlorodifluoroacetate 
• 74031-42-8 (3,3,3-trifluoroprop-1-enyl)benzene 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 776313-42-9 1,1-difluoro-3-phenylpropyl phenyl sulfide 
• 100-42-5 styrene 
• 776313-51-0 1,1-difluoro-3-phenylpropyl phenyl sulfoxide 

Downstream Products

• 1350432-99-3 C₉H₉F₂⁽¹⁸⁾F 

Relevant academic research and scientific papers

Synthesis of gem-difluoroalkenes by copper-catalyzed regioselective hydrodefluorination of 1-trifluoromethylalkenes

A copper-catalyzed regioselective hydrodefluorination of 1-trifluoromethylalkenes with hydrosilanes has been developed. The copper catalysis is compatible with several functional groups, including alkyl chloride, ether, ester, nitrile, and imide moieties, to form the corresponding gem-difluoroalkenes in good yields. Additionally, asymmetric induction is also possible by using the chiral DTBM-SEGPHOS ligand, and gem-difluoroalkene with point chirality at the allylic position is obtained with high enantioselectivity.

Stereoselective formation of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes with lithium organoborates

A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem?difluoroalkenes in mild conditions was described. The combination of lithium organoborate and ZnBr2 generated in situ lithium ar

Palladium-Catalyzed Carbonylative Cross-Coupling of Difluoroalkyl Halides with Alkylboranes under 1 atm of CO

A palladium catalyzed carbonylative cross-coupling of difluoroalkyl halides with alkyl-9-BBN under 1 atm of CO has been developed. The reaction shows broad substrate scope and high functional group tolerance, even toward complex pharmaceuticals, providing

Copper(I)-catalyzed stereoselective defluoroborylation of aliphatic gem-difluoroalkenes

This study reports a method for the stereoselective copper(I)catalyzed defluoroborylation of aliphatic gem-difluoroalkenes to afford (Z)-monofluoro-substituted borylalkenes. Gem-difluoro-alkenes bearing a variety of functional groups were efficiently borylated with high stereoselectivity. A theoretical study of the reaction mechanism is also described.

Heterogeneous Catalytic Hydroarylation of Olefins at a Nanoscopic Aluminum Chlorofluoride

We report on hydroarylation reactions of arenes with olefins under very mild conditions catalyzed heterogeneously by aluminum chlorofluoride (ACF; AlClxF3?x, x≈0.05–0.25). The reactions of benzene and toluene with ethylene or propylene proceed with high conversions to afford various alkylated arenes. For cyclohexene and 1-hexene, the reactions require higher temperatures and the conversions are lower. ACF also catalyzes the hydroarylation of 1,3,5-trifluorobenzene and pentafluorobenzene with ethylene and propylene. The alkylations of arenes with non-fluorinated olefins resemble typical Friedel–Crafts chemistry to give rise to Markovnikov regioselectivity. The reaction of CF3CH=CH2 with benzene proceeds with anti-Markovnikov regioselectivity to give the fluorinated olefin PhCHCH=CF2 and the alkylation product PhCH2CH2CF3 as products of C?F and C?H activation.

Catalytic C-F activation via cationic group IV metallocenes

The catalytic cleavage of sp3 C-F bonds of 3,3,3-trifluoropropene (TFP) can be performed using cationic group IV metallocenes and an excess of triisobutylaluminum. The isobutyl adduct 1,1-difluoro-5-methyl-hex-1-ene (DFMH) as well as 3,3-(diflu

Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block

Bromodifluorophenylsulfanylmethane has been demonstrated to be a highly versatile gem-difluoromethylene (CF2) building block via the reaction of difluorophenylsulfanylmethyl radical with olefins. gem-Difluoroalkenes and products containing a mi

REACTION OF 3,3,3-TRIFLUOROPROPENE WITH BENZENE OVER Al2O3 TREATED WITH CF3Cl

The reaction between 3,3,3-trifluoropropene and benzene in a vapor phase was carried out over various Al2O3.Trifluoropropylbenzene was obtained selectively when CF3Cl-treated Al2O3 was used as a catalyst.