49802-34-8Relevant academic research and scientific papers
PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS
-
Page/Page column 94, (2009/02/11)
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR 119 G protein-coupled receptor modulator therapy. These novel compounds have the structure Formula I or Formula IA.
Substituted cyclohexylaminopyrimidines
-
, (2008/06/13)
Compounds of formula I where R1is hydrogen, chlorine, fluorine or methyl, R2and R3, which may be the same or different from each other, are hydrogen, halogen, cyano, (C1-C4)-alkyl, vinyl, ethynyl, (C
Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
Kobayashi, Yoshiro,Nagai, Takabumi,Kumadaki, Itsumaro,Takahashi, Masaaki,Yamauchi, Takashi
, p. 4382 - 4387 (2007/10/02)
The Friedel-Crafts reaction of 1,1,1-trifluoropropene with benzene and its derivatives was accomplished in the presence of fluorine-containing acid catalysts.The reaction proceeded at the terminal carbon atom of the olefin to give 3,3,3-trifluoropropylated aromatic compounds.The scope and limitations of this reaction were examined.This substituent was found to be ortho- and para-directing.Keywords - Friedel-Crafts reaction; trifluoropropene; trifluoropropyl; Nafion-H; hydrogen fluoride; boron trifluoride; tetrafluoroboric acid; benzene; trifluoropropylation
Hydrolysis of hydroxybenzotrifluorides and fluorinated uracil derivatives. A general mechanism for carbon fluorine bond labilization
Sakai,Santi
, p. 1079 - 1084 (2007/10/09)
The kinetics of hydrolysis of o and p hydroxybenzotrifluoride (1 and 2) and 1 trifluoromethyl 2 (4 hydroxyphenyl) ethylene (3) and the uracil derivatives 5 difluoromethyluracil (5) and 1 methyl 5 difluoromethyluracil (6) are described. Compounds 1 and 2 h
