498577-19-8

Basic information

• Product Name: Phenol, 2-methoxy-4-(1-pyrrolidinylmethyl)-
• CAS NO: 498577-19-8
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 498577-19-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenol, 2-methoxy-4-(1-pyrrolidinylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-methoxy-4-(1-pyrrolidinylmethyl)-(498577-19-8)
• EPA Substance Registry System: Phenol, 2-methoxy-4-(1-pyrrolidinylmethyl)-(498577-19-8)

Safety Data

• Hazardous Substances Data: 498577-19-8(Hazardous Substances Data)

Upstream product

• 415928-53-9 2-methoxy-4-(N-morpholinyl)methylphenol 
• 109162-32-5 2-methoxy-4-(piperidin-1-ylmethyl)phenol 
• 19861-69-9 4-((dimethylamino)methyl)-2-methoxyphenol 
• 123-75-1 pyrrolidine 
• 121-33-5 vanillin 
• 115062-93-6 1-(4-hydroxy-3-methoxybenzyl)piperdin-1-ium chloride 

Downstream Products

• 125660-98-2 4-((benzyloxy)methyl)-2-methoxyphenol 
• 109162-32-5 2-methoxy-4-(piperidin-1-ylmethyl)phenol 
• 115062-93-6 1-(4-hydroxy-3-methoxybenzyl)piperdin-1-ium chloride 

Relevant articles and documents

Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect

A series of benzoisoxazoleylpiperidine derivatives were synthesized by using the multi-target strategies and their potent affinities for dopamine (DA), serotonin (5-HT) and human histamine H3 receptors have been evaluated. Of these compounds, t

Demonstration of in Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents

After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. When aged, known reactivators of OP-inhibited AChE are no longer effective. Realkylation of aged AChE may provide a route to reversing aging. We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. Our lead compound (C8) from an in vitro screen successfully resurrected 32.7 and 20.4% of the activity of methylphosphonate-aged and isopropyl phosphate-aged electric-eel AChE, respectively, after 4 days. C8 displays properties of both resurrection (recovery from the aged to the native state) and reactivation (recovery from the inhibited to the native state). Resurrection of methylphosphonate-aged AChE by C8 was significantly pH-dependent, recovering 21% of activity at 4 mM and pH 9 after only 1 day. C8 is also effective against isopropyl phosphate-aged human AChE.

HISTAMINE-3 RECEPTOR ANTAGONISTS

This invention is directed to a compound of the formula Ia or Ib. as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper and hypo motility and acidic secretion of the gastro- intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.