19861-69-9

Upstream product

• 121-33-5 vanillin 
• 124-40-3 dimethyl amine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 115319-87-4 4-<(dimethylamino)methyl>-2-methoxy-3-(methylthio)phenol 
• 109162-32-5 2-methoxy-4-(piperidin-1-ylmethyl)phenol 
• 498577-19-8 2-methoxy-4-(pyrrolidin-1-ylmethyl)phenol 
• 498-00-0 4-hydroxymethyl-2-methoxyphenol 
• 125660-98-2 4-((benzyloxy)methyl)-2-methoxyphenol 
• 115062-93-6 1-(4-hydroxy-3-methoxybenzyl)piperdin-1-ium chloride 
• 100-02-7 4-nitro-phenol 
• 115319-81-8 2-methoxy-5-(methylthio)-3-(phenylthio)-1,4-benzoquinone 
• 115319-80-7 2-Methoxy-3-phenylsulfanyl-[1,4]benzoquinone 
• 112520-80-6 3-(methylthio)-2-methoxy-1,4-benzoquinone 
• 109685-10-1 3-deuterio-2-methoxy-1,4-benzoquinone 
• 80464-91-1 2-methoxy-5-(3'-methyl-2'-butenyl)-1,4-benzoquinone 
• 127757-17-9 5-(3'-hydroxy-3'-methylbutenyl)-2-methoxy-4-<(dimethylamino)methyl>phenol 
• 127757-24-8 2-methoxy-5-(3'-methyl-2'-butenyl)-4-<(dimethylamino)methyl>phenol 

Relevant academic research and scientific papers

The sustainable heterogeneous catalytic reductive amination of lignin models to produce aromatic tertiary amines

A novel heterogeneous catalytic process for efficient reductive amination is developed in the presence of heterogeneous zirconium-based catalysts, in which N,N-dimethylformamide is used as the solvent, low-molecular-weight amine source and reductant. Aromatic tertiary amines have been produced from lignin-derived aromatic aldehydes via the mild Leuckart reaction with ZrO2 or ZrO(OH)2 as catalysts, for instance, a 95.8% yield of N,N-dimethyl-1-(3,4,5-trimethoxyphenyl)methanamine in a 100% selectivity is obtained from the reductive amination of 3,4,5-trimethoxybenzaldehyde under mild conditions.

Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase

Acetylcholinesterase (AChE) is an essential enzyme that can be targeted by organophosphorus (OP) compounds, including nerve agents. Following exposure to OPs, AChE becomes phosphylated (inhibited) and undergoes a subsequent aging process where the OP-AChE adduct is dealkylated. The aged AChE is unable to hydrolyze acetylcholine, resulting in accumulation of the neurotransmitter in the central nervous system (CNS) and elsewhere. Current therapeutics are only capable of reactivating inhibited AChE. There are no known therapeutic agents to reverse the aging process or treat aged AChE. Quinone methides (QMs) have been shown to alkylate phosphates under physiological conditions. In this study, a small library of novel quinone methide precursors (QMPs) has been synthesized and examined as potential alkylating agents against model nucleophiles, including a model phosphonate. Computational studies have been performed to evaluate the affinity of QMPs for the aged AChE active site, and preliminary testing with electric eel AChE has been performed.