499220-14-3

Basic information

• Product Name: sunitinib malate
• Synonyms: sunitinib malate
• CAS NO: 499220-14-3
• Molecular Weight: 532.569
• Mol File: 499220-14-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: sunitinib malate(CAS DataBase Reference)
• NIST Chemistry Reference: sunitinib malate(499220-14-3)
• EPA Substance Registry System: sunitinib malate(499220-14-3)

Safety Data

• Hazardous Substances Data: 499220-14-3(Hazardous Substances Data)

Upstream product

• 342641-94-5 sunitinib 
• 97-67-6 (S)-Malic acid 

Downstream Products

• 326914-13-0 5-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid(2-diethylamino-ethyl)-amide 
• 557795-19-4 sunitinib 

Relevant articles and documents

Malic acid lin's preparation method

The present invention relates to a sunitinib malate preparation method, wherein particularly 2,4-dimethyl-5-aldehyde-1H-pyrrole-3-carboxylic acid is adopted as a starting raw material, carboxyl activation with carbonyl diimidazole is performed, the obtained material and N, N-diethylethylenediamine are subjected to condensation under catalysis of 1-hydroxybenzotriazole to obtain an intermediate 1, the intermediate 1 and 5-fluoro-2-oxindole react to obtain sunitinib, and the sunitinib and malic acid are directly subjected to salifying without separation so as to obtain the target product. The method of the present invention has characteristics of easy operation, high yield and high product purity, and is suitable for industrial production.