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Product FOB Price Min.Order Supply Ability Supplier
Cas No: 50-12-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
(S)-MEPHENYTOIN Manufacturer CAS:50-12-4
Cas No: 50-12-4
No Data 10 Gram 10000 Metric Ton/Month Hubei XinRunde Chemical Co., Ltd Contact Supplier
Manufacturer supply CAS 50-12-4 with best quality
Cas No: 50-12-4
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
2,4-Imidazolidinedione,5-ethyl-3-methyl-5-phenyl- CAS NO.50-12-4
Cas No: 50-12-4
No Data 100 Gram 500 Metric Ton/Month Changchun JuShengyuan Import and Export Trading Co.,Ltd Contact Supplier
Cas No: 50-12-4
No Data 1 Gram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
3-Methyl-5-ethyl-5-phenylhydantoin CAS NO 50-12-4 from China supplier factory price
Cas No: 50-12-4
USD $ 20.0-30.0 / Gram 10 Gram 2 Metric Ton/Week Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
2,4-Imidazolidinedione,5-ethyl-3-methyl-5-phenyl- CAS NO.50-12-4
Cas No: 50-12-4
No Data 10 Gram 500 Kilogram/Month Changchun Artel lmport and Export trade company Contact Supplier
Factory supply3-Methyl-5-ethyl-5-phenylhydantoin with Good Price CAS NO.50-12-4
Cas No: 50-12-4
USD $ 10.0-10.0 / Kilogram 1 Kilogram Kilogram/Day Wuhan Xinhao Biotechnology Co., Ltd. Contact Supplier
5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione CAS NO.50-12-4
Cas No: 50-12-4
No Data 10 Gram 500 Kilogram/Week Zibo Hangyu Import&Export Co., Ltd Contact Supplier
Cas No: 50-12-4
No Data 1 Kilogram 100 Kilogram/Week HANGZHOU YUNUO CHEMICAL CO.,LTD Contact Supplier

50-12-4 Usage


Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.






rac-Mephenytoin is an anticonvulsant agent.

Manufacturing Process

23 parts sodium was dissolved in 300 parts of ethanol and added to 160 parts of 5-phenylcyanacetamide in 750 parts of ethanol. A mixture was cooled straight away and a sodium salt of amide precipitated as a white powder. 200 parts of ethyl iodide was added to this mixture and heated for 1.5 hours. The ethanol was distilled off, water was added to the residue and rapidly hardened oil precipitated. After recrystallization from ethanol, 5-ethyl-5- phenylacetamide afforded; MP: 116°C.100 parts of sodium hydroxide was solved in 500 parts of water and added to 83 parts of bromine by cooling. 5-Ethyl-5-phenylacetamide was added to above prepared mixture. It dissolved quickly, whereupon all mass was heated some time, cooled and stood at room temperature some hours. Then a solution of sodium bisulfite was added before the formed precipitate dissolved. The reaction mixture was filtered, the filtrate was acidified to give rapidly hardened oil. After recrystallization from ethanol 5-ethyl-3-methyl-5-phenylhydantoin was yielded as the bright needles; MP: 201°-202°C.

Brand name

Mesantoin (Novartis).

Therapeutic Function

Anticonvulsant, Antiepileptic

Biological Activity

CYP2C19 substrate. Anticonvulsant.

Biochem/physiol Actions

CYP2B6 and CYP2C19 substrate; anticonvulsive, antiepileptic.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hemorrhage, changes in teeth and supporting structures. Human mutation data reported. An experimental teratogen. An FDA proprietary drug used as an anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.

50-12-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (UC177)  (±)-Mephenytoin   50-12-4 UC177-5MG 4,058.73CNY Detail
Sigma (UC177)  (±)-Mephenytoin   50-12-4 UC177-10MG 7,142.85CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione

1.2 Other means of identification

Product number -
Other names Phenantoin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50-12-4 SDS

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