50-46-4

Basic information

• Product Name: 5,8-Dihydroisoquinoline-5,8-dione
• Synonyms: 5,8-Dihydroisoquinoline-5,8-dione;5,8-Isoquinolinedione;Nsc76882;isoquinoline-5,8-dione
• CAS NO: 50-46-4
• Molecular Formula: C₉H₅NO₂
• Molecular Weight: 159.1415
• Mol File: 50-46-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 333.6°Cat760mmHg
• Flash Point: 159.9°C
• Appearance: /
• Density: 1.374g/cm³
• Vapor Pressure: 0.000135mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 5,8-Dihydroisoquinoline-5,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-Dihydroisoquinoline-5,8-dione(50-46-4)
• EPA Substance Registry System: 5,8-Dihydroisoquinoline-5,8-dione(50-46-4)

Safety Data

• Hazardous Substances Data: 50-46-4(Hazardous Substances Data)

Usage

General Description

5,8-Dihydroisoquinoline-5,8-dione is a chemical compound with the molecular formula C9H7NO2. It is a yellowish solid with a distinct odor and is found naturally in certain plant species. It is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential applications in organic electronic devices and as a synthetic precursor for various organic compounds. It is important to handle 5,8-Dihydroisoquinoline-5,8-dione with caution as it may pose risks to human health and the environment if not properly handled and disposed of.

InChI:InChI=1/C9H5NO2/c11-8-1-2-9(12)7-5-10-4-3-6(7)8/h1-5H

Upstream product

• 1125-60-6 isoquinolin-5-ylamine 
• 55087-23-5 5,8-dimethoxyisoquinoline 
• 2439-04-5 5-hydroxyisoquinoline 
• 119-65-3 isoquinoline 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 54879-66-2 acetaldehyde dimethyl acetal 
• 54879-79-7 acetaldehyde dimethyl acetal 
• 1432611-60-3 N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide 
• 54879-36-6 N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide 
• 54879-54-8 5,8-dimethoxy-3-methyl-2-tosyl-1,2-dihydroisoquinoline 
• 607-32-9 5-nitroisoquinoline 
• 1127-49-7 5,8-diaminoisoquinoline 
• 156901-61-0 8-amino-5-nitro-isoquinoline 

Downstream Products

• 46492-08-4 benz[g]isoquinoline-5,10-dione 
• 118680-81-2 7-aminoisoquinoline-5,8-dione 

Relevant articles and documents

Synthesis and biological evaluation of caulibugulones A-E

The marine bryozoan metabolites caulibugulone A-E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.

Ezrin inhibitors and methods of making and using

The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

Exploitation of a tuned oxidation with N -haloimides in the synthesis of caulibugulones A-D

Marine alkaloids caulibugulones A-D were synthesized in six steps starting from the readily available 2,5-dimethoxybenzaldehyde. Pomeranz-Fritsch reaction of N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide proceeded smoothly to gi