1127-49-7

Usage

Uses

Used in Organic Synthesis:
Isoquinoline-5,8-diamine is utilized as a key intermediate in the synthesis of various organic compounds due to its ability to participate in a wide range of chemical reactions, contributing to the creation of complex molecular structures.
Used in Pharmaceutical Research:
In the pharmaceutical industry, isoquinoline-5,8-diamine serves as a building block for the development of biologically active compounds, leveraging its versatile chemical properties to enhance drug discovery and design.
Used in Medicinal Chemistry:
Isoquinoline-5,8-diamine is employed as a valuable component in medicinal chemistry, where its capacity to form complex structures aids in the design and synthesis of potential therapeutic agents.
Used in Drug Discovery:
As a part of drug discovery efforts, isoquinoline-5,8-diamine is used to explore its potential as an inhibitor of biological enzymes and receptors, which could lead to the development of new pharmaceuticals with novel mechanisms of action.

Upstream product

• 1125-60-6 isoquinolin-5-ylamine 
• 156901-61-0 8-amino-5-nitro-isoquinoline 
• 119-65-3 isoquinoline 
• 607-32-9 5-nitroisoquinoline 

Downstream Products

• 50-46-4 isoquinoline-5,8-dione 
• 84289-03-2 DA 295 
• 228574-27-4 6-chloro-7-((4-methoxyphenyl)amino)isoquinoline-5,8-dione 
• 228574-31-0 6-chloro-7-(2-hydroxyethylphenyl)amino-5,8-isoquinolinedione 
• 296776-09-5 6-chloro-7-(4-isopropylphenyl)amino-5,8-isoquinolinedione 

Relevant academic research and scientific papers

Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof

Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one bicyclic 6-6 (0:1, 0:2, 1:1, 1:2) aza heteroaromatic keratin dyeing compound with one or two N-oxides. A method for oxidative dyeing of kerat

7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8- isoquinolinediones

6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

Cycloaddition Routes to Azaanthraquinone Derivatives. 1. Use of Azadienophiles

The mono- and diazanaphthoquinones underwent facile cycloaddition with cyclic and alicyclic dienes, and in the majority of these cycloadditions the initial 1:1-cycloadducts or their tautomers and intermediate products formed in the oxidation procedure leading to the final azaanthraquinones were isolated.Quinoline-5,8-dione and 1-methoxy-1,3-cyclohexadiene gave the 8-methoxy isomer in an essentially regiospecific cycloaddition; isoquinoline-5,8-dione, however, gave both the 5- and 8-methoxy isomers in a 2.8:1 ratio.These structural assignments were verified by alternative syntheses of the possible isomers using heteroatom-directed lithiation procedures.