156901-61-0

Basic information

• Product Name: 8-Isoquinolinamine, 5-nitro-
• CAS NO: 156901-61-0
• Molecular Formula: C9H7N3O2
• Molecular Weight: 189.173
• Mol File: 156901-61-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-Isoquinolinamine, 5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Isoquinolinamine, 5-nitro-(156901-61-0)
• EPA Substance Registry System: 8-Isoquinolinamine, 5-nitro-(156901-61-0)

Safety Data

• Hazardous Substances Data: 156901-61-0(Hazardous Substances Data)

Upstream product

• 607-32-9 5-nitroisoquinoline 
• 74-89-5 methylamine 

Downstream Products

• 1338952-13-8 C₉H₈ClN₃*ClH 
• 296776-08-4 6-chloro-7-(4-trifluoromethoxyphenyl)amino-5,8-isoquinolinedione 
• 296776-09-5 6-chloro-7-(4-isopropylphenyl)amino-5,8-isoquinolinedione 
• 228574-31-0 6-chloro-7-(2-hydroxyethylphenyl)amino-5,8-isoquinolinedione 
• 228574-27-4 6-chloro-7-((4-methoxyphenyl)amino)isoquinoline-5,8-dione 

Relevant articles and documents

Amination of Some Nitroisoquinolines with Liquid Methylamine/Potassium Permanganate

5-Nitro-, 3-methyl-5-nitro-, 5,7-dinitro-, 5-chloro-8-nitro- and 8-chloro-5-nitroisoquinoline (1a-e) as well as 5-nitroisoquinoline N-oxide (1f) are aminated with a liquid methylamine solution of potassium permanganate (LMA/PP) to the corresponding mono- or mono- and bis(methylamino)-substituted nitro compounds 2 (a-m). 1-Nitroisoquinoline (1g) is aminated with LMA/PP to 1-(methylamino)isoquinoline (2n).Quantum-chemical calculations for some mononitroisoquinolines suggest that, in general, the experimentally observed regioselectivity of the amination is controlled by an interaction of frontal molecular orbitals (FMO) of the reagents. - Key Words: Methylaminations / Calculations, FMO / Isoquinolines / Aminations / Nitro compounds