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50-60-2 Usage

description

Phentolamine is an α-adrenergicreceptor antagonist approved for use by the U.S.Food and Drug Administration (FDA) in 1952. Approved uses of phentolamine currently include (1) diagnosis of pheochromocytoma,(2) treatment of hypertension in pheochromocytoma, and (3) prevention of tissue necrosis after norepinephrine extravasation. Anearly use of injectable phentolamine involved the management of impotence (erectile dysfunction). Phentolamine is a short-acting, competitive antagonist at peripheral o-adrenergic receptors. It antagonizes both a and ozreceptors,thus blocking the actions of the circulating catecholamines epinephrine and norepinephrine. Phentolamine also stimulates β-adrenergic receptors in the heart and lungs.

Pharmacology

Analogues of the imidazoline adrenergic amines were among the first synthetic adrenergic blocking agents to be identified. Phentolamine is the only compound from this class that is still clinically available. Phentolamine is a competitive non-selective α1- and α2-adrenergic receptor blocker of relatively short duration of action. It causes vasodilatation and a fall in blood pressure resulting from the blockade of both post-junctional vascular α1- and α2-adrenoceptors. It also antagonises the vasoconstrictor response to noradrenaline and adrenaline infusions. Enhanced neural release of noradrenaline due to presynaptic α2-blockade may contribute to the positive inotropic and chronotropic effects of Regitine on cardiac muscle.

Uses

Different sources of media describe the Uses of 50-60-2 differently. You can refer to the following data:
1. Phentolamine is a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Phentolamine is used mainly in the diagnosis of pheochromocytoma and to control or prevent paroxysmal hypertension immediately prior to or during pheochromocytomectomy. Phentolamine has been used to treat hypertensive crises secondary to MAO inhibitor/sympathomimetic amine interactions and rebound hypertension on withdrawal of clonidine, propranolol or other antihypertensive agents.
2. Phentolamine is used for peripheral blood circulation disorders, in particular in the beginning stages of gangrene, for treatment of trophic ulcers of the extremities, bedsores, and frostbite.
3. Anti-adrenergic. Phentolamine is used to prevent or control hypertensive episodes that occurin patients with pheochromocytoma. It also has been used incombination with papaverine to treat impotence.

clinical use

The clinical effects of phentolamine include peripheral vasodilation and tachycardia.Vasodilation results from both direct relaxation of vascular smooth muscle and a blockade. The drug produces positive inotropic and chronotropic effects,leading to an increase in cardiac output.In smaller doses, the positive inotropic effect can predominate and raise blood pressure; in larger doses, peripheral vasodilation can mask the inotropic effect and lower blood pressure.These actions make phentolamine useful in treating hypertension caused by increased circulating levels of epinephrine and norepinephrine, as occurs in pheochromocytoma. The effects of phentolamine in treating impotence are mediated by α-adrenergic blockade in penile blood vessels. Actions of the drug cause relaxation of the trabecular cavernous smooth muscles and dilation of the penile arteries; this increases arterial blood flow into the corpus cavernosa and subsequently causes an erection. Phentolamine is administered IV or IM but can be injected subcutaneously to prevent local tissue necrosis when vasoconstrictor drugs extravasate. The pharmacokinetics of phentolamine is largely unknown;10% of a parenteral dose is excreted in the urine unchanged.

Carcinogenicity / mutagenicity

Experimental data have established that phentolamine lacks mutagenic potential in bacteria, and does not induce chromosomal aberrations in mammalian somatic cells in vivo. Long-term carcinogenicity studies have not been conducted with phentolamine.

Overdosage

No deaths due to acute poisoning with phentolamine have been reported. Overdosage with parenterally administered phentolamine is characterized chiefly by cardiovascular disturbances, such as arrhythmias, tachycardia, hypotension, and possibly shock. In addition, the following might occur: excitation, headache, sweating, pupillary contraction, visual disturbances, nausea, vomiting, diarrhea, or hypoglycemia. There is no specific antidote; treatment consists of appropriate monitoring and supportive care. Substantial decreases in blood pressure or other evidence of shock-like conditions should be treated vigorously and promptly.

Description

Phentolamine is also a derivative of imidazoline that exhibits a direct α-adrenoblocking, muscle-relaxant effect on smooth muscle as well as cholinomimetic, histamine, and sympathomimetic effects. The chemical variation of its structure permits a few of its properties to be more expressed. For example, the aforementioned tolazoline, 2-benzyl-2-imidazoline, a structural analog of phentolamine, has more of an expressed muscle-relaxant effect on smooth muscle than an α-adrenoblocking effect.

Originator

Regitine, Ciba, US ,1952

Definition

ChEBI: A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used fo the treatment of hypertension.

Indications

Human erectile tissue has a population of membrane receptors that are predominantly of the -adrenoceptor subtype. Phentolamine (Vasomax) is a nonselective - adrenoceptor blocking agent (see Chapter 11), and like other such agents, it has been used to treat ED. Nonselective adrenoceptor antagonists may provoke a reflex that increases both sympathetic outflow and the release of norepinephrine.

Manufacturing Process

199.24 parts of N-(p-methylphenyl)-m'-hydroxyphenylamine and 77.52 parts of 2-chloromethylimidazoline hydrochloride are heated for sixteen hours in an oil bath having a temperature of 150°C, while stirring and introducing a current of nitrogen. The viscous contents of the flask are then cooled to about 100°C, mixed with 400 parts by volume of hot water, and stirred for a short time.After further cooling to about 60°C, 200 parts by volume of water and 500 parts by volume of ethyl acetate at 60°C are added, and the aqueous layer is separated. The excess of starting material may be recovered from the ethyl acetate.The aqueous portion is chilled in a cooling chamber at -10°C, whereupon the hydrochloride of 2-[N-(p-methylphenyl)-N-(m'-hydroxyphenyl)-aminomethyl]imidazoline crystallizes. Upon being concentrated and cooled the mother liquor yields a further quantity of the hydrochloride. The combined quantities of hydrochloride are treated with a small quantity of cold water, dried with care, and washed with ethyl acetate. The product is then crystallized from a mixture of alcohol and ethyl acetate, and there is obtained a hydrochloride melting at 239°-240°C.

Brand name

Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].

Therapeutic Function

Adrenergic blocker

General Description

Phentolamine isthe more effectiveα -blocker.

Mechanism of action

Its mechanism of action is as an α-adrenergic antagonist of both α1- and α2-receptors, causing vasodilation and reduction in peripheral resistance. When administered by intracavernosal injection, it is thought to cause relaxation of the cavernous smooth muscles and vasodilation of the penile arteries. This results in increased arterial blood flow into the corpus cavernosa as well as swelling and elongation of the penis. Venous outflow also is reduced, possibly as a result of increased venous resistance. Phentolamine is slowly released into venous circulation with minimal, if any, systemic effects. Time to peak effect is within 10 minutes, and duration of action when used with papaverine is 1 to 6 hours.

Clinical Use

Phentolamine has been used orally and intracavernosally in the treatment of ED. Following oral administration, phentolamine has a plasma half-life of about 30 minutes and a duration of action of 2 to 4 hours. An intracavernosal injection of phentolamine results in the drug reaching maximum serum levels in about 20 to 30 minutes. It is rapidly metabolized. Phentolamine has been used in combination with papaverine, chlorpromazine, and vasoactive peptides in the treatment of ED.

Side effects

Side effects of phentolamine are dose related. It may cause orthostatic hypotension, reflex tachycardia, cardiac arrhythmias, and rarely, myocardial infarction. Phentolamine also may reduce sperm motility in vitro.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Phentolamine, 2-[[N-(3′-hydroxyphenyl)-para-toluidion]methyl]-2- imidazoline (12.2.8), is synthesized by alkylation of 3-(4-methylanilino)phenol using 2-chloromethylimidazoline [36, 37].

Check Digit Verification of cas no

The CAS Registry Mumber 50-60-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 50-60:
(4*5)+(3*0)+(2*6)+(1*0)=32
32 % 10 = 2
So 50-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N3O/c1-13-5-7-15(8-6-13)20(11-14-10-18-12-19-14)16-3-2-4-17(21)9-16/h2-9,18,21H,10-12H2,1H3

50-60-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name phentolamine

1.2 Other means of identification

Product number -
Other names Fentolamin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50-60-2 SDS

50-60-2Synthetic route

4-methyl-3'-hydroxydiphenylamine
61537-49-3

4-methyl-3'-hydroxydiphenylamine

2-(chloromethyl)-2-imidazoline hydrochloride
13338-49-3

2-(chloromethyl)-2-imidazoline hydrochloride

phentolamine
50-60-2

phentolamine

Conditions
ConditionsYield
With triethyl phosphite In toluene for 6h; Heating;49%
With 1,2-dichloro-benzene
With 1,2-dichloro-benzene
ethylenediamine
107-15-3

ethylenediamine

N-<3-acetoxy-phenyl>-N-p-tolyl-glycine nitrile

N-<3-acetoxy-phenyl>-N-p-tolyl-glycine nitrile

phentolamine
50-60-2

phentolamine

Conditions
ConditionsYield
With carbon disulfide
With hydrogen sulfide
meta-nitrophenol
554-84-7

meta-nitrophenol

phentolamine
50-60-2

phentolamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc; ammonium chloride
2: triethyl phosphite / toluene / 0.75 h / 20 °C
3: triethyl phosphite / toluene / 6 h / Heating
View Scheme
2-(chloromethyl)-imidazoline
50342-08-0

2-(chloromethyl)-imidazoline

4-methyl-3'-hydroxydiphenylamine
61537-49-3

4-methyl-3'-hydroxydiphenylamine

phentolamine
50-60-2

phentolamine

Conditions
ConditionsYield
In toluene Reflux;
1-methylcyclohexan-4-one
589-92-4

1-methylcyclohexan-4-one

phentolamine
50-60-2

phentolamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: styrene; 10 wt% Pd(OH)2 on carbon / toluene / 24 h / 140 °C / 3750.38 Torr / Flow reactor
2: toluene / Reflux
View Scheme
p-cresol
106-44-5

p-cresol

phentolamine
50-60-2

phentolamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; palladium on activated charcoal / toluene / 140 °C / 1500.15 Torr / Flow reactor
2: styrene; 10 wt% Pd(OH)2 on carbon / toluene / 24 h / 140 °C / 3750.38 Torr / Flow reactor
3: toluene / Reflux
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

phentolamine
50-60-2

phentolamine

phentolamine mesylate
65-28-1

phentolamine mesylate

Conditions
ConditionsYield
In ethanol pH=5 - 6;99%
phentolamine
50-60-2

phentolamine

methyl iodide
74-88-4

methyl iodide

3-[N-(1-methyl-4,5-dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol; hydriodide

3-[N-(1-methyl-4,5-dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol; hydriodide

50-60-2Downstream Products

50-60-2Relevant articles and documents

Continuous Synthesis of Aryl Amines from Phenols Utilizing Integrated Packed-Bed Flow Systems

Ichitsuka, Tomohiro,Kobayashi, Shū,Koumura, Nagatoshi,Sato, Kazuhiko,Takahashi, Ikko

, p. 15891 - 15896 (2020/07/13)

Aryl amines are important pharmaceutical intermediates among other numerous applications. Herein, an environmentally benign route and novel approach to aryl amine synthesis using dehydrative amination of phenols with amines and styrene under continuous-flow conditions was developed. Inexpensive and readily available phenols were efficiently converted into the corresponding aryl amines, with small amounts of easily removable co-products (i.e., H2O and alkanes), in multistep continuous-flow reactors in the presence of heterogeneous Pd catalysts. The high product selectivity and functional-group tolerance of this method allowed aryl amines with diverse functional groups to be selectively obtained in high yields over a continuous operation time of one week.

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