50-73-7

Basic information

• Product Name: 2,3,5-Trichlorobenzoic acid
• Synonyms: 2,3,5-TRICHLOROBENZOIC ACID;RARECHEM AL BE 0200;TIMTEC-BB SBB003322;2,3,5-trichloro-benzoicaci;2,3,5-TRICHLOROBENZOIC ACID PESTANAL100;2,3,5-Trichlorobenzoic;2,3,5-TBA;2,3,5-Trichlorobenzoic acid,97%
• CAS NO: 50-73-7
• Molecular Formula: C₇H₃Cl₃O₂
• Molecular Weight: 225.46
• EINECS: 210-380-1
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 50-73-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 166-167 °C(lit.)
• Boiling Point: 329.4 °C at 760 mmHg
• Flash Point: 153 °C
• Appearance: light beige crystalline powder
• Density: 1.5599 (estimate)
• Vapor Pressure: 7.14E-05mmHg at 25°C
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• PKA: 2.09±0.25(Predicted)
• BRN: 2097064
• CAS DataBase Reference: 2,3,5-Trichlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-Trichlorobenzoic acid(50-73-7)
• EPA Substance Registry System: 2,3,5-Trichlorobenzoic acid(50-73-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: DH7525000
• HazardClass: IRRITANT
• Hazardous Substances Data: 50-73-7(Hazardous Substances Data)

Usage

Chemical Properties

light beige crystalline powder

Uses

2,3,5-Trichlorobenzoic Acid enhances dechlorination of congeners in Aroclor 1248.

InChI:InChI=1/C7H3Cl3O2/c8-3-1-4(7(11)12)6(10)5(9)2-3/h1-2H,(H,11,12)/p-1

Upstream product

• 2789-92-6 3,5-dichloroantranilic acid 
• 56961-86-5 2,3,5-trichloro-toluene 
• 7697-37-2 nitric acid 
• 56961-75-2 2,3,5-trichlorobenzaldehyde 
• 7664-93-9 sulfuric acid 
• 133-90-4 chloramben 
• 25186-47-4 3,5-dichlorotoluene 
• 355133-69-6 2,5-dichloro-3-nitrobenzaldehyde 
• 6361-23-5 2,5-dichloro-benzaldehyde 
• 98-86-2 acetophenone 
• 7647-01-0 hydrogenchloride 
• 6575-02-6 2,3,5-trichloro-benzonitrile 
• 60580-56-5 1-(2,3,5-trichloro-phenyl)-ethanone 

Downstream Products

• 86569-79-1 methyl 2,3,5-trichlorobenzoate 
• 4681-17-8 2,3,5-trichlorophenylmethanol 
• 50834-09-8 2,3,5-trichlorobenzamide 
• 42221-48-7 2,3,5-trichloro-benzoyl chloride 
• 86569-88-2 2,3,5-trichloro-benzoic acid ethyl ester 

Relevant articles and documents

Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents

A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, 1H NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity.

Pharmacologically active CNS compounds

The invention provides compounds of formula (I) wherein at least one of R1, R2 and R3 is chloro and the others are selected from hydrogen and chloro; and R4 and R5 are the same or different and are each alkyl or hydrogen. The compounds may be used for the treatment or prophylaxis of a neurodegenerative of other neurological disorder of the CNS, the aetiology of which includes excessive release of the neurotransmitter glutamate.