500-02-7

Usage

Uses

Used in Fragrance Industry:
4-isopropylcyclohex-2-en-1-one is used as a fragrance ingredient for its ability to provide a fresh, woody, and slightly citrusy scent. It is commonly found in essential oils, particularly in Eucalyptus camaldulensis and lavender, where it contributes to the overall aroma profile.
Used in Flavor Industry:
In the flavor industry, 4-isopropylcyclohex-2-en-1-one is used as a flavoring agent to impart a unique taste and aroma to various food and beverage products. Its characteristic flavor profile makes it suitable for use in the development of new and innovative flavors.
Used in Pharmaceutical Industry:
4-isopropylcyclohex-2-en-1-one serves as an intermediate in the synthesis of various pharmaceutical compounds. One such example is its role in the synthesis of β-Phellandrene (P294560), a terpene compound with potential antiproliferative effects on human renal adenocarcinoma and amelanotic melanoma cells. This makes it a valuable compound in the development of new drugs and therapies for cancer treatment.
Used in Chemical Synthesis:
Due to its unique chemical structure, 4-isopropylcyclohex-2-en-1-one is utilized as a building block in the synthesis of other organic compounds. Its versatility in chemical reactions allows it to be used in the production of various chemicals, including those with potential applications in the agrochemical, material science, and specialty chemical industries.

InChI:InChI=1/C9H14O/c1-7(2)8-3-5-9(10)6-4-8/h3,5,7-8H,4,6H2,1-2H3

Upstream product

• 97857-20-0 menth-2-ene-1,7-diol 
• 24903-94-4 7-methyl-1,6-octadiene-3-one 
• 38651-65-9 (1R,5S)-(+)-nopinone 
• 513-20-2 sabinaketone 
• 7664-93-9 sulfuric acid 
• 24903-95-5 nopinone 
• 56-23-5 tetrachloromethane 
• 2009-00-9 sabinene 
• 108-24-7 acetic anhydride 
• 64-17-5 ethanol 
• 110716-99-9 (1R,5S)-sabina ketone 
• 7732-18-5 water 
• 57422-87-4 (E)-1-(3-methylbut-1-en-1-yl)piperidine 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 99-83-2 p-mentha-1,5-diene 
• 619-62-5 1-methyl-4-(1-methylethyl)-2-cyclohexen-1-ol 
• 4581-63-9 (+/-)-4-isopropyl-cyclohex-2-enone semicarbazone 
• 120892-76-4 3,4-diisopropylcyclohexanone 
• 215456-39-6 4-isopropyl-2-cyclohexenone oxime 
• 215733-60-1 2,3-Dihydroxy-4-isopropyl-cyclohex-2-enone 
• 118376-84-4 trans-3-Vinyl-4-isopropylcyclohexanone 
• 284021-86-9 (4-isopropyl-1-cyclohexenyloxy)dimethylphenylsilane 
• 57422-89-6 4-isopropyl-6-methylcyclohex-2-en-1-one 
• 555-10-2 beta-phellandrene 

Relevant academic research and scientific papers

Total syntheses of (+)-adunctins C and D: Assignment of their absolute configurations

The first total synthesis of (+)-adunctin C (ent-1) and (+)-adunctin D (2), two monoterpene-substitued dihydrochalcones isolated from Piper aduncum (Piperaceae), was achieved. A regioselective oxidative [3 + 2] cycloaddition of acylphloroglucinol with (-)-β-phellandrene was developed to construct their unique spirobenzofuran skeleton. The absolute configurations of natural adunctins 1 and 2 were thus assigned through these endeavors. This journal is

FUSED RING COMPOUNDS

Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

Synthetic method of stealthy ketone (by machine translation)

The method disclosed by the invention is characterized in that the, method for synthesizing: the octrexone by the step of reacting synthetic enamine with tetrahydropyrrole and isovaleraldehyde; under 2 - 6h a basic condition of water to 2 - obtain a latent ketone crude; product comprises the following 2 - steps of: refluxing under, the alkaline condition, of water; and, distilling off the solvent, under reduced pressure, to obtain a latent ketone crude product . (by machine translation)

PINENE-DERIVED DIISOCYANATES

A pinene-derived diisocyanate compound, a process for forming a pinene-derived diisocyanate compound, and an article of manufacture containing a polyurethane polymer are disclosed. The process for forming the pinene-derived diisocyanate compound includes oxidizing the pinene to form a pinene-derived ketone compound, converting the pinene-derived ketone compound to a diamine compound in subsequent reaction steps, and reacting the diamine compound with phosgene to form the pinene-derived diisocyanate compound. The polyurethane polymer is synthesized in a reaction between a pinene-derived diisocyanate compound and a polyol.

Synthesis of α,β-unsaturated carbonyl compounds via a visible-light-promoted organocatalytic aerobic oxidation

α,β-Unsaturated ketones and aldehydes have been synthesized from their corresponding silyl enol ethers in a straightforward protocol involving a visible-light promoted organocatalytic, aerobic oxidation reaction. A cheap organic dye was used catalytically in these reactions as the photosensitizer.

A stereoselective, Sm(ii)-mediated approach to decorated cis-hydrindanes: Synthetic studies on faurinone and pleuromutilin

The cis-hydrindane motif is found in a number of natural products that display important biological activity. A flexible, stereoselective approach to the framework has been developed that features highly diastereoselective, SmI2-mediated cyclisations. The strategy has been exploited in the first synthesis of the proposed structure of faurinone and an approach to the skeleton of the antibacterial natural product, pleuromutilin.

Total synthesis of eudesmane terpenes: Cyclase phase

A full account of synthetic efforts toward dihydrojunenol, one of the lowest oxidized members of the eudesmane family of natural products, is presented. The final synthetic sequence illustrates a nine-step, gram-scale, enantioselective route to this bicyclic terpene with excellent stereocontrol and in 21% overall yield.

A flexible, stereoselective approach to the decorated cis-hydrindane skeleton: Synthesis of the proposed structure of faurinone

A flexible, stereoselective approach to the cis-hydrindane motif found in a number of biologically active natural products that utilizes highly diastereoselective SmI2-mediated cyclizations of aldehyde and halide substrates was demonstrated. Aldehydes were prepared to investigate the stereoselectivity of the proposed SmI2-mediated construction of the cis-hydrindane system. Treatment of aldehydes with SmI2 in THF and tBuOH resulted in successful cyclization and construction of three contiguous stereocenters. This cyclization proceeds through reduction of the aldehyde and addition of the resulting ketyl-radical anion to the alkene through anti-transition structure to give samarium (III) enolates. It was observed that SmI2-mediated halide-alkene cyclizations provide an easy alternative for the synthesis of less oxygenated targets.

Synthesis of (1S,4R)-4-isopropyl-1-methyl-2-cyclohexen-1-ol, the aggregation pheromone of the ambrosia beetle Platypus quercivorus, its racemate, (1R,4R)- and (1S,4S)-isomers

(S)-Perillyl alcohol was converted to (R)-cryptone (91.5-93% ee) in six steps, which was then treated with methyllithium to give (1S,4R)-4-isopropyl-1-methyl-2-cyclohexen-1-ol, the aggregation pheromone of the ambrosia beetle Platypus quercivorus. The racemic pheromone was also prepared by methylation of (±)-cryptone. Both (1R,4R)- and (1S,4S)-isomers (98% ee) of the pheromone were synthesized from the enantiomers of dihydrolimonene oxide.

COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY

The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.