2009-00-9

Basic information

• Product Name: (+)-SABINENE, TERPENE STANDARD
• Synonyms: (+)-SABINENE, TERPENE STANDARD;(1R)-4-methylene-1-(1-methylethyl)-bicyclo[3.1.0]hexane;(1R,5R)-(+)-sabinene;4(10)-thujene,(1R,5R)-(+)-;bicyclo[3.1.0]hexane,4-methylene-1-(1-methylethyl)-,(1R)-;d-sabinene;Bicyclo3.1.0hexane, 4-methylene-1-(1-methylethyl)-, (1R,5R)-;(1R,5R)-1-Isopropyl-4-methylenebicyclo[3.1.0]hexane, (1R,5R)-4(10)-Thujene
• CAS NO: 2009-00-9
• Molecular Formula: C₁₀H₁₆
• Molecular Weight: 136.23404
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 2009-00-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 163-164 °C(lit.)
• Flash Point: 36 °C
• Appearance: /
• Density: 0.844 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.468
• CAS DataBase Reference: (+)-SABINENE, TERPENE STANDARD(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-SABINENE, TERPENE STANDARD(2009-00-9)
• EPA Substance Registry System: (+)-SABINENE, TERPENE STANDARD(2009-00-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-10
• Safety Statements: 16-26-36
• RIDADR: 1993
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 2009-00-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2009-00-9 differently. You can refer to the following data:
1. A component of juniper berry oil
2. A component of juniper berry oil having antibacterial and antifungal activity.

Upstream product

• 763-10-0 geranyl diphosphate 
• 2009-00-9 sabinene 
• 5389-87-7 1-chloro-3,7-dimethylocta-2,6-diene 

Downstream Products

• 99-87-6 4-methylisopropylbenzene 
• 2158-59-0 cryptone 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 78-79-5 isoprene 
• 562-74-3 TERPINEN-4-OL 
• 3484-42-2 2-methyl-5-(1-methylethyl)-(1α,2α,5α)-bicyclo[3.1.0]hexan-2-ol 
• 1620144-76-4 C₂₀H₂₅Cl₃OS₂ 
• 10408-16-9 [3.1.0]hexane, 4-methylene-1-(1-methylethyl)bicyclo 
• 5163-66-6 formic acid p-menth-1-en-4-yl ester 
• 201472-65-3 (1S,6S)-6-(propan-2-yl)-3-oxabicyclo[4.1.0]heptan-2-one 
• 201472-64-2 (1S,6R)-6-(propan-2-yl)-2-oxabicyclo[4.1.0]heptan-3-one 
• 99-85-4 crithmene 
• 1248388-57-9 (1R,5R,7S)-5-isopropyl-2-methyl-7-[(E)-prop-1-en-1-yl]-6-oxabicyclo[3.2.1]oct-2-ene 

Relevant articles and documents

Acorenone B: AChE and BChE inhibitor as a major compound of the essential oil distilled from the ecuadorian species niphogeton dissecta (Benth.) J.F. macbr

This study investigated the chemical composition, physical proprieties, biological activity, and enantiomeric analysis of the essential oil from the aerial parts of Niphogeton dissecta (culantrillo del cerro) from Ecuador, obtained by steam distillation. The qualitative and quantitative analysis of the essential oil was realized by gas chromatographic and spectroscopic techniques (GC-MS and GC-FID). Acorenone B was identified by GC-MS and NMR experiments. The enantiomeric distribution of some constituents has been assessed by enantio-GC through the use of a chiral cyclodextrin-based capillary column. We identified 41 components that accounted for 96.46% of the total analyzed, the major components were acorenone B (41.01%) and (E)-β-ocimene (29.64%). The enantiomeric ratio of (+)/(-)-β-pinene was 86.9:13.1, while the one of (+)/(-)-sabinene was 80.9:19.1. The essential oil showed a weak inhibitory activity, expressed as Minimal Inhibitory Concentration (MIC), against Enterococcus faecalis (MIC 10 mg/mL) and Staphylococcus aureus (MIC 5 mg/mL). Furthermore, it inhibited butyrylcholinesterase with an IC50 value of 11.5 μg/mL. Pure acorenone B showed inhibitory activity against both acetylcholinesterase and butyrylcholinesterase, with IC50 values of 40.8 μg/mL and 10.9 μg/mL, respectively.

Isotope sensitive branching and kinetic isotope effects to analyse multiproduct terpenoid synthases from Zea mays

Multiproduct terpene synthases TPS4-B73 and TPS5-Delprim from Zea mays exhibit isotopically sensitive branching in the formation of mono- and sesquiterpene volatiles. The impact of the kinetic isotope effects and the stabilization of the reactive intermediates by hyperconjugation along with the shift of products from alkenes to alcohols are discussed.

Monoterpene synthase activities in leaves of Picea abies (L.) Karst. and Quercus ilex L.

In addition to direct ecological functions in the interaction of plants with the environment, the emission of monoterpenes, especially from the foliage of evergreen trees, is of great importance for the production of ozone and photochemical oxidants in the troposphere. In the present work, we established a reproducible non-radioactive standard enzyme assay and characterized monoterpene synthase activities in needles of Norway spruce (Picea abies (L.) Karst.) and in leaves of holm oak (Quercus ilex L.). In Norway spruce, the dominant monoterpenes formed were α-pinene, camphene, and to a lesser extent β-pinene and limonene. In holm oak, α-pinene, sabinene, and β-pinene were the main products, while limonene was a minor component. Under optimum conditions, in both Norway spruce and holm oak, monoterpene formation remained constant up to 180 min and 90 min, respectively, and varied with the buffer and Mg2+ and Mn2+ concentrations used. Optimum temperature for monoterpene synthase activity was 40°C in both species; optimal pH ranged between 6.5 and 7.5 in both species. Apparent Michaelis- constants for the substrate GDP were ca. 17.9 ± 5.1 μM for Norway spruce and ca. 69.4 ± 22.1 μM for holm oak. Molecular weight determination by FPLC indicated that the monoterpene synthases in Norway spruce and holm oak have native molecular weights of ca. 59 and 50 kDa, respectively. (C) 2000 Elsevier Science Ltd.