500016-41-1

Upstream product

• 75177-61-6 2-chloro-3,5-dimethoxybenzyl chloride 
• 151-50-8 potassium cyanide 
• 6652-32-0 3,5-dimethoxybenzylchloride 
• 13388-75-5 3,5-dimethoxyphenylacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 5859-85-8 1-(bromomethyl)-2-chloro-3,5-dimethoxybenzene 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 

Downstream Products

• 142688-96-8 2-(2-chloro-3,5-dimethoxyphenyl)acetic acid 
• 1020256-33-0 ethyl 2-chloro-3,5-dimethoxyphenylacetate 
• 1020256-34-1 ethyl 2-chloro-3,5-dimethoxy-6-formyl-phenylacetate 

Relevant academic research and scientific papers

FGFR INHIBITOR AND APPLICATION THEREOF

An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).

Simple and efficient method for the halogenation of oxygenated aromatic compounds

An efficient and mild method for the chlorination and bromination of oxygenated aromatics, with good regioselectivity and excellent yields, using a combination of HX/H2O2/AcOH in petroleum ether is presented. The effect of ultrasound was investigated. Georg Thieme Verlag Stuttgart ? New York.

Synthesis of chlorohomophthalic acids, key intermediates in the synthesis of chlorinated isocoumarins

Efficient synthesis of chlorohomophthalic acids (6) and (7), key intermediates in the synthesis of chlorinated isocoumarins (3) and (4) is described.