5859-85-8

Upstream product

• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 5859-84-7 2-chloro-3,5-dimethoxybenzyl alcohol 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 

Downstream Products

• 1192851-74-3 C₂₄H₃₀ClN₅O₆ 
• 1430737-52-2 tert-butyl(((1R,3aS,4S,7aR)-4-(2-chloro-3,5-dimethoxybenzyl)-4,7a-dimethyl-5-methyleneoctahydro-1H-inden-1-yl)oxy)-dimethylsilane 
• 1430737-39-5 2-chloro-1-(iodomethyl)-3,5-dimethoxybenzene 

Relevant academic research and scientific papers

FGFR INHIBITOR AND APPLICATION THEREOF

An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).

Diastereoselective synthesis of complex cis-hexahydroindanes by reductive alkylation

An efficient and operationally simple approach to complex cis-hexahydroindanes is reported. Upon Birch reduction of unprotected, C4-alkylated tetrahydroindanols and electrophilic trapping of the tetrasubstituted enolate, cis-fused products are formed with a new stereogenic quaternary carbon. The reaction is convergent, completely diastereoselective, and shows a broad scope with regard to the electrophile.