500131-76-0

Basic information

• Product Name: (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one
• Synonyms: (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one
• CAS NO: 500131-76-0
• Molecular Weight: 451.681
• Mol File: 500131-76-0.mol

Chemical Properties

• CAS DataBase Reference: (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one(500131-76-0)
• EPA Substance Registry System: (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one(500131-76-0)

Safety Data

• Hazardous Substances Data: 500131-76-0(Hazardous Substances Data)

Upstream product

• 105262-86-0 2-((tert-butyldimethylsilyl)oxy)benzyl bromide 
• 500131-75-9 (4R)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 

Downstream Products

• 500131-79-3 tert-butyl (2R)-2-(2-tert-butyldimethylsilyloxybenzyl)-2-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate 
• 500131-78-2 [(2R)-2-(2-tert-butyldimethylsilyloxybenzyl)hexahydro-2-pyridinyl]methanol 
• 500131-80-6 tert-butyl (2R)-2-(2-hydroxybenzyl)-2-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate 
• 500131-77-1 (2R)-2-[(2R)-2-(2-tert-butyldimethylsilyloxybenzyl)-2-(hydroxymethyl)tetrahydro-1(2H)-pyridinyl]-2-phenyl-1-ethanol 

Relevant articles and documents

Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy

Enantiomerically pure (3′R)- and (3′S)-3′,4′-dihydrospiro[piperidine-2,3′ (2′H)-benzopyran]s (R)-10 and (S)-10 were successfully synthesized according to the CN(R,S) methodology with the aim of serving as a pattern for the generation of related spirocyclic compounds. Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine (-)-2. One of them was selected and used for the preparation of amines (R)-17 and (S)-17 starting from (-)-2 and (+)-2, respectively. The enantiomeric purity of all final aminochroman derivatives was determinated by capillary electrophoresis using β-cyclodextrin as the chiral selector.