414869-76-4Relevant articles and documents
Asymmetric synthesis of an MMP-3 inhibitor incorporating a 2-alkyl succinate motif
Ashcroft, Christopher P.,Challenger, Stephen,Derrick, Andrew M.,Storey, Richard,Thomson, Nicholas M.
, p. 362 - 368 (2013/09/06)
An efficient and practical synthesis is presented of the pharmaceutically active MMP-3 inhibitor UK-370,106 (1) via an olefination/catalytic asymmetric hydrogenation sequence. Commercially available 5-bromo-2-iodotoluene was converted in two steps to the
Novel olefination process to itaconate and succinate derivatives
-
, (2008/06/13)
An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives.