500353-20-8

Basic information

• Product Name: Benzoic acid, 4-[[[4-(dimethylamino)cyclohexylidene]amino]oxy]-2-fluoro-, 1,1-dimethylethyl ester
• CAS NO: 500353-20-8
• Molecular Formula: C19H27FN2O3
• Molecular Weight: 350.433
• Mol File: 500353-20-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[[4-(dimethylamino)cyclohexylidene]amino]oxy]-2-fluoro-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[[4-(dimethylamino)cyclohexylidene]amino]oxy]-2-fluoro-, 1,1-dimethylethyl ester(500353-20-8)
• EPA Substance Registry System: Benzoic acid, 4-[[[4-(dimethylamino)cyclohexylidene]amino]oxy]-2-fluoro-, 1,1-dimethylethyl ester(500353-20-8)

Safety Data

• Hazardous Substances Data: 500353-20-8(Hazardous Substances Data)

Upstream product

• 203985-55-1 4-dimethylaminocyclohexanone oxime 
• 500353-15-1 tert-butyl 2,4-difluorobenzoate 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 176661-76-0 (1,4-dioxa-spiro[4.5]dec-8-yl)dimethylamine 
• 40594-34-1 4-(dimethylamino)cyclohexanone 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Relevant articles and documents

Preparation of 8-amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and several fluorinated derivatives via [3,3]-sigmatropic rearrangement of O-aryloximes

Methodology to prepare 8-amido-2-amino-1,2,3,4-tetrahydro-2-dibenzofurans, analogues with a fluorine substituent incorporated in the 6-, 7-, and 9-positions, and a difluorinated analogue with fluorines in the 6- and 9-positions is described. The tetrahydrodibenzofuran ring systems are prepared by acid-catalyzed [3,3]-sigmatropic rearrangement of O-aryloximes. Regioselective reactions to prepare the requisite O-aryloxime intermediates from commercially available fluorobenzene derivatives are discussed.