500574-46-9Relevant academic research and scientific papers
Synthesis of polyfunctionalized Troger's Base analogs derived from ethacridine (6,9-diamino-2-ethoxyacridine)
Tatibouet,Demeunynck,Lhomme
, p. 4375 - 4395 (1996)
In the search for chemical probes of DNA conformations, we report an efficient synthesis of new Troger's Base analogs derived from polyfunctionalized aminoacridines treated with a stoichiometric amount of formaldehyde in trifluoroacetic acid. For the more sensitive aminoacridines, the Troger's Bases were obtained by nucleophilic substitution of the chloro group of the 'pre-formed' corresponding Troger's Base.
