Synthesis of polyfunctionalized Troger's Base analogs derived from ethacridine (6,9-diamino-2-ethoxyacridine)

Article abstract of DOI:10.1080/00397919608003840

In the search for chemical probes of DNA conformations, we report an efficient synthesis of new Troger's Base analogs derived from polyfunctionalized aminoacridines treated with a stoichiometric amount of formaldehyde in trifluoroacetic acid. For the more sensitive aminoacridines, the Troger's Bases were obtained by nucleophilic substitution of the chloro group of the 'pre-formed' corresponding Troger's Base.

Full text of DOI:10.1080/00397919608003840

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Synthetic Communications: An
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Organic Chemistry
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Synthesis of Polyfunctionalized
Tröger's Base Analogs Derived
from Ethacridine (6,9-
Diamino-2-ethoxyacridine)
A. Tatibouët a , M. Demeunynck a & J. Lhomme a
a LEDSS , Université J. Fourier , BP 53, 38041
Grenoble cedex 9, France
Published online: 23 Aug 2006.
To cite this article: A. Tatibouët , M. Demeunynck & J. Lhomme (1996) Synthesis
of Polyfunctionalized Tröger's Base Analogs Derived from Ethacridine (6,9-
Diamino-2-ethoxyacridine), Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 26:23, 4375-4395, DOI:
10.1080/00397919608003840
To link to this article: http://dx.doi.org/10.1080/00397919608003840
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