500735-23-9Relevant articles and documents
Isoquinolinone synthesis by SNAr reaction: A versatile route to imidazo[4,5-h]isoquinolin-9-ones
Snow, Roger J.,Butz, Tanja,Hammach, Abdelhakim,Kapadia, Suresh,Morwick, Tina M.,Prokopowicz III, Anthony S.,Takahashi, Hidenori,Tan, Jonathan D.,Tschantz, Matt A.,Wang, Xiao-Jun
, p. 7553 - 7556 (2007/10/03)
Reaction of 2-chlorobenzonitriles with β-ketoesters in an SNAr reaction, followed by cyclization in acid provides a versatile route to isoquinolones. Starting from 2,6-dichloro-3-nitrobenzonitrile 7, sequential displacement of the chlorines by