500788-93-2Relevant articles and documents
GLUCOSE METABOLISM MODULATING COMPOUNDS
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, (2016/11/14)
The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyperglycemia.
HYPOGLYCEMIC DIHYDROPYRIDONES
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Page/Page column 57, (2010/04/03)
The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods o
New entry to the asymmetric synthesis of (-)-lasubine I and (+)-subcosine I
Yamazaki, Naoki,Atobe, Masakazu,Kibayashi, Chihiro,Aoyagi, Sakae
scheme or table, p. 433 - 439 (2009/12/05)
A new synthetic entry to (-)-lasubine I and (+)-subcosine I has been established by employing the (S)-allylalkoxy benzylamine as a chiral synthon. The synthesis involves the formation of an α,β-unsaturated lactone by RCM reaction followed by an intramolec
Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists
Xie, Yuli,Raffo, Anthony,Ichise, Masanori,Deng, Shixian,Harris, Paul E.,Landry, Donald W.
scheme or table, p. 5111 - 5114 (2009/07/18)
Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyridone