500999-99-5

Basic information

• Product Name: Ethanamine, 2-[[(4-methoxyphenyl)diphenylmethyl]thio]-
• Synonyms: monomethoxytrityl cysteamine;Mmt-chloride
• CAS NO: 500999-99-5
• Molecular Formula: C22H23NOS
• Molecular Weight: 349.497
• Mol File: 500999-99-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Ethanamine, 2-[[(4-methoxyphenyl)diphenylmethyl]thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanamine, 2-[[(4-methoxyphenyl)diphenylmethyl]thio]-(500999-99-5)
• EPA Substance Registry System: Ethanamine, 2-[[(4-methoxyphenyl)diphenylmethyl]thio]-(500999-99-5)

Safety Data

• Hazardous Substances Data: 500999-99-5(Hazardous Substances Data)

Upstream product

• 156-57-0 2-mercaptoethylamine hydrochloride 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 60-23-1 Cysteamine 
• 847-83-6 p-methoxytrityl alcohol 

Downstream Products

• 501000-02-8 2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-benzoylamino)-4-{2-[(4-methoxy-phenyl)-diphenyl-methylsulfanyl]-ethylcarbamoyl}-butyric acid tert-butyl ester 
• 475575-54-3 2-(4-amino-benzoylamino)-4-{2-[(4-methoxy-phenyl)-diphenyl-methylsulfanyl]-ethylcarbamoyl}-butyric acid tert-butyl ester 
• 501000-01-7 2-amino-4-{2-[(4-methoxy-phenyl)-diphenyl-methylsulfanyl]-ethylcarbamoyl}-butyric acid tert-butyl ester 
• 501000-00-6 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-{2-[(4-methoxy-phenyl)-diphenyl-methylsulfanyl]-ethylcarbamoyl}-butyric acid tert-butyl ester 

Relevant articles and documents

Solid-phase insertion of N-mercaptoalkylglycine residues into peptides

N-mercaptoalkylglycine residues were inserted into peptides by reacting N-free amino groups of peptides, which were initially synthesized on 2-chlorotrityl resin (Cltr) using the Fmoc/tBu method, with bromoacetic acid and subsequent nucleophilic replacement of the bromide by reacting with S-4-methoxytrityl- (Mmt)/S-trityl- (Trt) protected aminothiols. The synthesized thiols containing peptide-peptoid hybrids were cleaved from the resin, either protected by treatment with dichloromethane (DCM)/trifluoroethanol (TFE)/acetic acid (AcOH) (7:2:1), or deprotected (fully or partially) by treatment with trifluoroacetic acid (TFA) solution using triethylsilane (TES) as a scavenger.

One-Pot Cyclization and Cleavage of Peptides with N-Terminal Cysteine via the N,S-Acyl Shift of the N-2-[Thioethyl]glycine Residue

We developed a one-pot method for peptide cleavage from a solid support via the N,S-acyl shift of N-2-[thioethyl]glycine and transthioesterification using external thiols to produce cyclic peptides through native chemical self-ligation with the N-terminal

Cricked nucleic acid

Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click acceptor moiety, and an optionally protected nucleobase (NB), which in some examples is an A, G, T, U, or C nucleobase. In some examples, the click nucleic acid monomer includes a N-vinyl thiol acetamide (VTA) backbone. In other examples the click nucleic acid monomer includes a N-vinyl thiol ethylamine (VTE) backbone. Methods of using such polymers, for example in place of naturally occurring nucleic acid polymer applications, such as DNA or RNA, and synthetic nucleic acid polymer applications, such as PNA or morpholino nucleic acids, are also disclosed.