1435-44-5

Usage

Uses

1. Used in the Chemical Industry:
1-Chloro-2,4-difluorobenzene is used as a starting material for the synthesis of various organic compounds, such as benzonorbornadienes and difluoroarenes. Its unique structure and functional groups make it a valuable intermediate in the production of specialty chemicals and pharmaceuticals.
2. Used in the Pharmaceutical Industry:
1-Chloro-2,4-difluorobenzene serves as a key building block in the development of new drugs and pharmaceutical compounds. Its chemical properties allow for further functionalization and modification, leading to the creation of novel molecules with potential therapeutic applications.
3. Used in the Material Science Industry:
1-Chloro-2,4-difluorobenzene can be utilized in the development of advanced materials, such as polymers and coatings, due to its reactive functional groups and compatibility with various polymerization techniques. Its incorporation into these materials can enhance their properties, such as chemical resistance, thermal stability, and mechanical strength.

InChI:InChI=1/C6H3ClF2/c7-5-2-1-4(8)3-6(5)9/h1-3H

Upstream product

• 90802-25-8 2,4-Difluor-benzoldiazonium-chlorid 
• 26120-88-7 2,4-dichlorobenzenesulfonyl fluoride 
• 38361-37-4 1-chloro-2,6-difluorobenzene 
• 75-05-8 acetonitrile 
• 225104-76-7 2,6-difluoro-3-chlorobenzoic acid 
• 372-18-9 1,3-Difluorobenzene 
• 1031226-45-5 (3-chloro-2,6-difluorophenyl)boronic acid 
• 108-90-7 chlorobenzene 

Downstream Products

• 1481-68-1 5-chloro-2,4-difluoronitrobenzene 
• 36556-37-3 1,3-dichloro-2,4-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 107-14-2 chloroacetonitrile 
• 333447-43-1 5-chloro-2,4-difluoro-1-iodobenzene 
• 2253-30-7 1,3-dichloro-4,6-difluorobenzene 
• 3939-09-1 2,4-difluorobenzonitrile 
• 252004-35-6 (3-chloro-2,6-difluoro-phenyl)-methanol 
• 190011-87-1 1-(3-chloro-2,6-difluoro-phenyl)-carboxaldehyde 
• 501-29-1 1-chloro-2-fluoro-4-methoxybenzene 
• 450-89-5 1-chloro-4-fluoro-2-methoxybenzene 
• 1221486-73-2 3-(2,4-Difluorophenylamino)-8-nitro-6H-dibenzo[b,e]oxepin-11-one 
• 261762-51-0 3-chloro-2,6-difluorophenol 
• 86386-73-4 fluconazole 

Relevant academic research and scientific papers

Reactions of aromatic compounds with xenon difluoride

Reactions of substituted benzenes C6H5R (R = Me, F, Cl, Br, CF3, NO2) with xenon difluoride in the presence of boron trifluoride–diethyl ether complex in weakly acidic (1,1,1,3,3-pentafluorobutane) and weakly basic media (acetonitrile) have been studied. These reactions lead to the formation of fluorobenzene derivatives FC6H4R (isomer mixture) together with isomeric difluorobenzenes and fluorinated and non-fluorinated biphenyls. The results have been compared with previously reported data obtained in other solvents using other catalysts.

Base-promoted protodeboronation of 2,6-disubstituted arylboronic acids

Facile based promoted deboronation of electron-deficient arylboronate esters was observed for arylboronates containing two ortho electron-withdrawing group (EWG) substituents. Among 30 representative boronates, only the diortho-substituted species underwe

Efficient oxidative chlorination of aromatics on saturated sodium chloride solution

An efficient metal-free system using saturated aqueous sodium chloride/aqueous ammonium chloride solution as chlorine source and potassium persulfate as a cheap oxidant for the chlorination of various aromatic compounds including deactivated ones has been developed that proceeds without any acid additive in an excellent regioselective manner. The easy-to-handle aqueous solution/acetonitrile biphasic system as solvent and no need for precautionary measures make this process very practical. Copyright

Rh(I)-catalyzed decarboxylative transformations of arenecarboxylic acids: Ligand- and reagent-controlled selectivity toward hydrodecarboxylation or heck-mizoroki products

(Chemical Equetion Presentation) A Rh(I)-based catalyst system has been developed to promote three types of decarboxylative transformations of arenecarboxylic acids: (1) hydrodecarboxylation, (2) Heck-Mizoroki olefination, and (3) conjugate addition. Scopes of reactions (1) and (2) were studied, and the ligand and reagent dependence of selectivity was explored.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

The Photolyses of 2,6- and 2,4-Difluorohalobenzenes

Photolyses of 2,6- and 2,4-difluorobromobenzenes in acetonitrile gave isomerized and brominated products in addition to 1,3-difluorobenzene produced by the dehalogenation.The reactions were compared with similar reactions of the corresponding chloro- and iodoarenes.In general, photolytic cleavage of the C-X bond of 2,6-difluorohalo(X)benzene was shown to proceed more easily than the corresponding 2,4-difluorohalo compound.