Cas 501446-70-4,1-Piperidinecarboxylic acid, 4-[(4-bromophenyl)(phenylmethyl)amino]-, 1,1-dimethylethyl ester

501446-70-4

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Basic information

Product Name: 1-Piperidinecarboxylic acid, 4-[(4-bromophenyl)(phenylmethyl)amino]-, 1,1-dimethylethyl ester
Synonyms:
CAS NO:501446-70-4
Molecular Formula: C23H29BrN2O2
Molecular Weight: 445.399
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[(4-bromophenyl)(phenylmethyl)amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[(4-bromophenyl)(phenylmethyl)amino]-, 1,1-dimethylethyl ester(501446-70-4)
EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[(4-bromophenyl)(phenylmethyl)amino]-, 1,1-dimethylethyl ester(501446-70-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 501446-70-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 501446-70-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,1,4,4 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 501446-70:
(8*5)+(7*0)+(6*1)+(5*4)+(4*4)+(3*6)+(2*7)+(1*0)=114
114 % 10 = 4
So 501446-70-4 is a valid CAS Registry Number.

501446-70-4Upstream product

501446-70-4Downstream Products

501446-71-5 C₁₈H₂₁BrN₂

501446-70-4Relevant academic research and scientific papers

Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

Skerlj, Renato,Bridger, Gary,Zhou, Yuanxi,Bourque, Elyse,McEachern, Ernest,Langille, Jonathan,Harwig, Curtis,Veale, Duane,Yang, Wen,Li, Tongshong,Zhu, Yongbao,Bey, Michael,Baird, Ian,Sartori, Michael,Metz, Markus,Mosi, Renee,Nelson, Kim,Bodart, Veronique,Wong, Rebecca,Fricker, Simon,Mac Farland, Ron,Huskens, Dana,Schols, Dominique

, p. 6950 - 6954 (2012/01/13)

A series of CCR5 antagonists were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics.

Piperidine derivatives useful as CCR5 antagonists

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Page/Page column 29; 35, (2010/02/05)

The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R9, R10, A and B are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

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