501648-78-8Relevant articles and documents
A selective HIV-protease assay based on a chromogenic amino acid
Badalassi, Fabrizio,Nguyen, Hong Khan,Crotti, Paolo,Reymond, Jean-Louis
, p. 3090 - 3098 (2007/10/03)
(2S,3S)-2-Amino-3-hydroxy-5-(4-nitrophenoxy)pentanoic acid (5) was prepared stereoselectively as the N-Fmoc, O-(tert-butyl)-protected derivative 5a in eleven steps from ethyl (E)-4-benzyloxypent-2-enoate (6). This protected amino acid was used for the sol
C-fucopeptides as selectin antagonists: Attachment of lipid moieties enhances the activity
Weltering, Thomas J.,Weitz-Schmidt, Gabriele,Wong, Chi-Huey
, p. 9033 - 9036 (2007/10/03)
The biological activity of a potent selectin antagonist could be 40-fold enhanced by attachment of a lipid moiety. Also an enantioselective synthesis of β,ω-dihydroxyamino acids by Sharpless asymmetric dihydroxylation (AD-reaction) allowed general access to this important class of compounds. Copyright (C) 1996 Elsevier Science Ltd.