501699-84-9

Upstream product

• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 134-96-3 syringic aldehyde 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 

Downstream Products

• 1351592-67-0 4-(3,5-dimethoxy-4-(2,2,2-trifluoroethoxy)benzyl)-7-ethoxyisoquinolin-8-ol 

Relevant academic research and scientific papers

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

Synthesis of novel (phenylalkyl)amines for the investigation of structure-activity relationships. Part 1. Mescalin derivatives

The synthesis and the spectroscopic data of 14 novel 4-substituted mescaline derivatives are reported. Starting from syringaldehyde (=4-hydroxy-3,5-dimethoxybenzaldehyde), several ethers were obtained from reaction with a series of corresponding saturated and unsaturated alkyl- and fluoroalkyl halides. Henry-reaction with MeNO2 or EtNO2 followed to afford the nitro-olefines, which were then reduced with AlH3 to the desired 2-phenytethyl- and 1-methyl-2-phenylethylamine derivatives.