5021-60-3

Basic information

• Product Name: N-(4-fluorophenyl)-4-methoxybenzamide
• Synonyms: N-(4-fluorophenyl)-4-methoxybenzamide;4'-FLUORO-4-METHOXYBENZANILIDE
• CAS NO: 5021-60-3
• Molecular Formula: C₁₄H₁₂FNO₂
• Molecular Weight: 245.25
• Mol File: 5021-60-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 300.1°C at 760 mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0.00115mmHg at 25°C
• Refractive Index: 1.602
• PKA: 12.62±0.70(Predicted)
• CAS DataBase Reference: N-(4-fluorophenyl)-4-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)-4-methoxybenzamide(5021-60-3)
• EPA Substance Registry System: N-(4-fluorophenyl)-4-methoxybenzamide(5021-60-3)

Safety Data

• Hazardous Substances Data: 5021-60-3(Hazardous Substances Data)

Usage

General Description

N-(4-fluorophenyl)-4-methoxybenzamide is a chemical compound with the molecular formula C14H12FNO2. It is a benzamide derivative with a 4-fluorophenyl group and a 4-methoxybenzene group. N-(4-fluorophenyl)-4-methoxybenzamide has potential applications in pharmaceutical and medicinal chemistry due to its ability to interact with biological systems. Its properties and potential uses may include its role as a building block in the synthesis of various organic compounds, as well as its potential pharmacological effects, such as acting as an enzyme inhibitor or modulator of biological pathways. Further research and studies may be needed to fully understand the range of its applications and potential benefits in various fields.

InChI:InChI=1/C14H12FNO2/c1-18-13-8-2-10(3-9-13)14(17)16-12-6-4-11(15)5-7-12/h2-9H,1H3,(H,16,17)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 371-40-4 4-fluoroaniline 
• 345-89-1 4-fluoro-4'-methoxybenzophenone 
• 696-63-9 4-Methoxybenzenethiol 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 1195-45-5 para-fluorophenyl isocyanate 
• 254454-47-2 4-methoxyphenylzinc iodide 
• 38695-26-0 1-(4-fluorobenzyl)-4-methoxybenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 1017572-83-6 (Z)-4-fluoro-N-(1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynylidene)aniline 

Relevant articles and documents

Cobalt catalysed aminocarbonylation of thiols in batch and flow for the preparation of amides

The synthesis of amides from thiols through a cobalt-catalyzed aminocarbonylation is shown. After optimizing all the reaction parameters, the methodology makes possible the obtention of amides with variable yields, while competing reactions such as the formation of disulfides and ureas can be limited. The process works well with aromatic thiols with electron donating groups (EDG) whereas other thiols give reaction with lower yields. The previous process has been transferred and optimized into flow equipment, thus allowing using less CO in a safer way, and permitting the scaling up of the synthesis. Two drugs, moclobemide and itopride were prepared with this methodology, albeit only in the second case with good results. A mechanistic pathway is proposed.

Microdroplets as Microreactors for Fast Synthesis of Ketoximes and Amides

The formation of amide bonds is one of the most valuable transformations in organic synthesis. Beckmann rearrangement is a well-known method for producing secondary amides from ketoximes. This study demonstrates the rapid synthesis of ketoximes and amides in microdroplets. Many factors are found to affect the yield, such as microdroplet generation devices, temperature, catalysts, and concentrations of reactants. In particular, the temperature has a great influence on the synthesis of amide, which is demonstrated by a sharp ascendance to the yield when the temperature was increased to 45 °C. The best amide yield (93.3%) can be obtained by using coaxial flowing devices, a sulfonyl chloride compound as a catalyst, and heating to 55 °C in microdroplets. The yields can reach 78.7-91.3% for benzoylaniline and 87.2-93.4% for benzophenone oximes in several seconds in microdroplets compared to 10.1-66.1% and 82.5-93.3% in several hours in the bulk phase. Apart from the dramatically decreased reaction time and enhanced reaction yields, the microdroplet synthesis is also free of severe reaction environments (anhydrous and anaerobic conditions). In addition, the synthesis in microdroplets also saves reactants and solvents and reduces the waste amounts. All of these merits indicate that the microdroplet synthesis is a high-efficiency green methodology.

Amide compound with antitumor activity and application of amide compound

The invention belongs to the technical field of pharmaceutical chemistry and particularly provides an amide compound with antitumor activity and application of the amide compound. The structural formula of the amide compound is shown as R1CONHR2, wherein R1 and R2 are independently selected from aryl or heterocycle. The biological activity test result of the compound shows that the compound has a good inhibition effect on histone methyl SET7. Good antitumor aspect development application prospects are achieved.